
Amine synthesis is industrially important, from the energy-intensive but highly impactful production of ammonia, to pharmaceutical molecules. Commercial amine manufacturing often involves multistep processes to build C–N bonds, whereas the addition reaction of amines and olefins can provide new amines in a single step. Additional efficiencies may be realized with control over proximal or vicinal stereocenters. A number of challenges face hydroamination catalysis, both in terms of understanding mechanism of highly efficient catalysts and developing new stereocontrol.