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Research

Underbakke Lab
Underbakke Lab

 

  • Signaling complexes

    Dynamic, scaffolded, multi-protein complexes are hallmarks of sophisticated cellular signaling systems. The higher-order architecture of these signaling complexes confers sensitivity, adaptability, control, and crosstalk. Signaling complex architecture is especially notable in the nervous system, where dynamic post-synaptic protein assemblies underlie the molecular origins of learning and memory.

  • Excitatory synapses exhibit characteristic proteinaceous microcompartments at the post-synaptic membrane known as the post-synaptic density (PSD). The PSD is richly organized into multi-protein complexes composed of glutamate receptors, scaffolding proteins, kinases, cytoskeleton, and G-protein signaling effectors.

    Excitatory synapses exhibit characteristic proteinaceous microcompartments at the post-synaptic membrane known as the post-synaptic density (PSD). The PSD is richly organized into multi-protein complexes composed of glutamate receptors, scaffolding proteins, kinases, cytoskeleton, and G-protein signaling effectors. The dynamic reorganizations of the higher-order architecture and composition of PSD signaling complexes underlies synaptic plasticity, learning, and memory.

  • noneuronalsignaling

    The diatomic gas nitric oxide (NO) serves dual physiological roles as both a signaling molecule and an inflammation agent. Nitric oxide synthases (NOS) are large, multi-domain hemoproteins responsible for production of NO. Emitted at minute concentrations, NO is a membrane-permeable paracrine signaling agent. Generated at high levels, NO acts as a potent cytotoxic weapon of the immune system.