Welcome to the Underbakke Lab! We study the architecture and assembly of scaffolded signaling complexes. We are located in the Roy J. Carver Department of Biochemistry, Biophysics & Molecular Biology at Iowa State University.
Loving HS, Underbakke ES. Conformational dynamics of FERM-mediated autoinhibition in Pyk2 tyrosine kinase. Biochemistry (2019) 58(36): 3767-3776.
Hanson QM, Carley JR, Gilbreath TJ, Smith BC, Underbakke ES. Calmodulin-induced conformational control and allostery underlying neuronal nitric oxide synthase activation. J. Mol. Biol. (2018) 430(7): 935-947