Highlighted Publications

Palhano Zanela TM, Zangiabadi M, Zhao Y, Underbakke ES. Molecularly imprinted nanoparticles reveal regulatory scaffolding features in Pyk2 tyrosine kinase. RSC Chem. Biol. (2024) 5: 447-453. PMC11078204

Jiang T, Wan G, Zhang H, Gyawali YP, Underbakke ES, Feng C. Probing protein dynamics in neuronal nitric oxide synthase by quantitative cross-linking mass spectrometry. Biochemistry. (2023) 62(15): 2232-2237. PMC10529231

Palhano Zanela TM, Woudenberg A, Romero Bello KG, Underbakke ES. Activation loop phosphorylation tunes conformational dynamics underlying Pyk2 tyrosine kinase activation. Structure. (2023) 31(4): 447-454e5.

Siang S, Underbakke ES, Roche J. Intricate coupling between the transactivation and basic-leucine zipper domains governs phosphorylation of transcription factor ATF4 by casein kinase 2. J. Biol. Chem. (2022) 298(3): 101633. PMC8881488

Agnew C, Ayaz P, Kashima R, Loving, HS, Ghatpande P, Kung JE, Underbakke ES, Shan Y, Shaw DE, Hata A, Jura N. Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization. Nat. Commun. (2021) 12: 4950. PMC8368100

Li X, Palhano Zanela TM, Underbakke ES, and Zhao Y. Controlling Kinase Activities by Selective Protection of Peptide Substrates, J. Am. Chem. Soc. (2021) 143(2): 639–643.

Loving HS, Underbakke ES. Conformational dynamics of FERM-mediated autoinhibition in Pyk2 tyrosine kinase. Biochemistry (2019) 58(36): 3767-3776.

Hanson QM, Carley JR, Gilbreath TJ, Smith BC, Underbakke ES. Calmodulin-induced conformational control and allostery underlying neuronal nitric oxide synthase activation. J. Mol. Biol. (2018) 430(7): 935-947

Underbakke ES, Iavarone AT, Chalmers MJ, Pascal BD, Novick S, Griffin PR, Marletta, MA. Nitric oxide-induced conformational changes in soluble guanylate cyclase. Structure (2014) 22(4) 602-11. PMC4001857 

Campbell MG, Underbakke ES, Potter CS, Carragher B, Marletta MA. Single particle EM reveals the higher order domain architecture of soluble guanylate cyclase. Proc. Natl. Acad. Sci USA. (2014) 111:2960-65. PMC3939929 

Underbakke ES, Surmeli NB, Smith BC, Wynia-Smith SJ, Marletta MA. Nitric oxide signaling. Comprehensive Inorganic Chemistry II, Vol. 3 Oxford: Elsevier (2013) 241-262.

Smith BC, Underbakke ES, Kulp DW, Schief W, Marletta MA. Nitric oxide synthase domain interfaces regulate electron transfer and calmodulin activation. Proc. Natl. Acad. Sci USA. (2013) 110:E3577-86. PMC3780838 

Underbakke ES, Iavarone AT, Marletta MA. Higher-order interactions bridge the nitric oxide receptor and catalytic domains of soluble guanylate cyclase. Proc. Natl. Acad. Sci USA. (2013) 110: 6777-82. PMC3637750 

Fernhoff NB, Derbyshire ER, Underbakke ES, Marletta MA. Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase (sGC) to nitric oxide. J. Biol. Chem.(2012) 287: 43053-62. PMC3522300 

Underbakke ES, Zhu Y, Kiessling LL. Protein footprinting in a complex milieu: identifying the interaction surfaces of the chemotaxis adapter protein CheW. J. Mol. Biol.(2011) 409: 483-495. PMC3179904

Underbakke ES, Zhu Y, Kiessling LL. Isotope-coded Affinity Tags with Tunable Reactivities for Protein Footprinting. Angew. Chem. Int. Ed. (2008) 47: 9677-80. PMC2790078

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