This work combines the vast sequence data with the large body of experimental protein and RNA structures that are available in uniquely innovative ways. The effort is a new project to combine the sequence and structure data.
Stabilities can distinguish some deleterious mutants from neutral ones. We find neutral mutants in general to have a narrower range of stabilities than deleterious ones. The deleterious mutants can be either much more or much less stable the neutral ones in general. See an example below for 98 mutants in 5 different proteins.
Validating Results Is Important to Avoid Erroneous Results (Hallucinations) As in Any Research ProjectPredicted Structures Are Now Sufficiently Reliable to Be Used for Validation
Treating the Language Embedding Layers as Data and Training Their Use
