Projects

Dynamics and Mechanisms

The project comprises of various sub-projects as follows: protein and RNA dynamics and biomolecular mechanisms

Higher order correlations in Biology

This work combines the vast sequence data with the large body of experimental protein and RNA structures that are available in uniquely innovative ways. The effort is a new project to combine the sequence and structure data. 

Medical and Evolution Applications

Stabilities can distinguish some deleterious mutants from neutral ones.  We find neutral mutants in general to have a narrower range of stabilities than deleterious ones.  The deleterious mutants can be either much more or much less stable the neutral ones in general.  See an example below for 98 mutants in 5 different proteins.