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About the Jernigan Laboratory

Welcome to Jernigan lab website!  Our primary focus is on computations on cells, proteins, nucleic acids, and small molecules, and their interactions. Often we work at the interface between sequence and structure and on the relationship between dynamics and mechanism.  In this latter case we often use simple models to improve comprehension of mechanisms. We often perform datamining and data analyses.

We are located at Department of Biochemistry, Biophysics, and Molecular Biology at Iowa State University Ames, Iowa. Our research is pushing toward the comprehension of the functions of and mechanisms of larger structures, and the use of large, diverse data to construct models of these.

Jernigan's research background:

  • Well known for mining information from protein structures and using it to evaluate predicted structures – Miyazawa-Jernigan potentials, elastic network deformations of structures, protein and ribosome mechanism.
  • Knowledgeable about a wide variety of research subjects, from the physical sciences to the biological sciences, from biomedicine to genomics, with a broad view of basic and applied research.
  • A recognized authority in computational and structural biology, with broader interests in bioinformatics, genomics, engineering and sub-cellular biology
  • High impact publications – 1 paper ~ 1900 citations, and 49 papers with > 100 citations each
  • 20,000 citations, h-index 67
  • Fellow, AAAS
  • Fellow,Biophysical Society
  • Recent book “Protein Actions” received 2018 PROSE award for best textbook in the biological and life sciences.

Current Projects

Improving Protein Sequence Matching

Understanding Protein Packing

Protein Engineering

Protein Mechanism from Dynamics

Simplifying and Improving Protein Calculations

Many-Body Correlations from Sequences

Connecting Sequence Correlations to Dynamics

Our Team

Jernigan Group



News release about out new Bioenergy Grant 

A new grant from NIH-HGRI Novel Use of Genome Information to Understand Mutations

Sayane Shome (recent grad) has moved to Stanford Medicine as a postdoc in the lab of Nima Aghaeepour!

Kejue Jia and Mesih Kilinc just completed in one day a massive multiple sequence algnment of 100,000 protein sequences!  The first of many to come....