Jernigan Laboratory

The Jernigan Laboratory

Welcome to Jernigan lab website! Our primary focus is on computations on cells, proteins, nucleic acids, and small molecules, and their interactions. Often we work at the interface between sequence and structure and on the relationship between dynamics and mechanism. In this latter case we often use simple models to improve comprehension of mechanisms. We often perform datamining and data analyses.

We are located at Department of Biochemistry, Biophysics, and Molecular Biology at Iowa State University Ames, Iowa. Our research is pushing toward the comprehension of the functions of and mechanisms of larger structures, and the use of large, diverse data to construct models of these.

Jernigan's research background:

Mining information from protein structures and using it to evaluate predicted structures – Miyazawa-Jernigan potentials, elastic network deformations of structures, protein and ribosome mechanism.
Knowledgeable about a wide variety of research subjects, from the physical sciences to the biological sciences, from biomedicine to genomics, with a broad view of basic and applied research.
A recognized authority in computational and structural biology, with broader interests in bioinformatics, genomics, structural biology, protein engineering and sub-cellular biology
High impact publications – 1 paper ~ 1900 citations, and 49 papers with > 100 citations each
20,000+ citations, h-index 67
Fellow, AAAS
Fellow, Biophysical Society
Book “Protein Actions” 2018 PROSE award for best textbook in the biological and life sciences.