Correlations in tRNA Sequences

The strongly correlated nucleotide pairs in the sequence correlation matrix and the dynamics correlation matrix are highly similar pattern

 

 

 

 

 

 

 

 

 

 

Working to establish the connection between RNA sequences, dynamics, and its alternative conformations.  The extraordinary number of tRNA sequences enables the extraction of higher order (3-body) correlations predicting the triplets of bases that interact in the structure.  This has been a long term goal of Kejue Jia and Jernigan in their research.

Top ranked triplets identify the interaction between HIV-1 nucleotide protein and RNA (PDB ID:1AIT).