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Publications

2021

Ramesh Kumar, J., Smith, J.P., Kwon, H., Smith, R.C. (2021) Use of clodronate liposomes to deplete phagocytic immune cells in Drosophila melanogaster and Aedes aegypti. Front Cell Dev Bio 9:627976. https://www.frontiersin.org/articles/10.3389/fcell.2021.627976/full

Hodge, J.M., Yurchenko, A.A., Karagodin, D.A., Masri, R.A., Smith, R.C., Gordeev, M.I., Sharakova, M.V.  (2021) The new Internal Transcribed Spacer 2 diagnostic tool clarifies the taxonomic position and geographic distribution of the North American malaria vector Anopheles punctipennis. Malar J. 20(1):141. https://malariajournal.biomedcentral.com/articles/10.1186/s12936-021-03676-4

Kwon, H., Simões, M.L., Reynolds, R. A., Dimopoulos, G., Smith, R.C. (2021) Additional feeding reveals differences in immune recognition and growth of Plasmodium parasites in the mosquito host. mSphere 6 (2): e00136-21. https://msphere.asm.org/content/6/2/e00136-21/article-info

Brackney, D.E., LaReau, J.C. Smith, R.C. (2021) Frequency matters: How successive feeding episodes by blood-feeding insect vectors influences disease transmission. PloS Pathogens 17(6): e1009590. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009590

Kwon, H.*, Mohammed, M.*, Franzén, O., Ankarklev, J., Smith, R.C. (2021) Single-cell analysis of mosquito hemocytes identifies signatures of immune cell sub-types and cell differentiation. eLife 10: e66192. https://elifesciences.org/articles/66192

Kwon, H., Hall, D.R., Smith, R.C. (2021) Identification of a prostaglandin E2 receptor that regulates mosquito oenocytoid immune cell function in limiting bacteria and parasite infection. Front. Immunol.  12: 680020. https://www.frontiersin.org/articles/10.3389/fimmu.2021.680020/abstract

2020

Tokarz, R.E., Smith, R.C. (2020) Crossover dynamics of Culex (Diptera: Culicidae) vector populations determine WNV transmission intensity. Journal of Medical Entomology 57(1):289-296. https://academic.oup.com/jme/advance-article/doi/10.1093/jme/tjz122/5532732

Field, E.N., Gehrke, E.J., Ruden, R.M., Adelman, J.S., Smith, R.C. (2020) An improved multiplex PCR assay for the identification of mosquito (Diptera: Culicidae) blood meals. Journal of Medical Entomology 57(2):557-562. https://academic.oup.com/jme/article/57/2/557/5601930?login=true

Reynolds, R. A., Kwon, H., Smith, R.C. (2020) 20-hydroxyecdysone (20E) primes innate immune responses that limit bacteria and malaria parasite survival in Anopheles gambiae. mSphere 5(2):e00983-19. https://msphere.asm.org/content/5/2/e00983-19

Smith, R.C. (2020) Highlights in Medical Entomology, 2019: Familiar Foes and New Frontiers. Journal of Medical Entomology 57(5): 1349-1353. https://academic.oup.com/jme/article/57/5/1349/5868617

Reynolds, R. A., Kwon, H., Alves E Silva, T.L., Olivas, J., Vega-Rodriguez, J., Smith, R.C. (2020) The 20-hydroxyecdysone agonist, halofenozide, promotes anti-Plasmodium immunity in Anopheles gambiae via the ecdysone receptor. Scientific Reports 10(1):21084. https://www.nature.com/articles/s41598-020-78280-8

2019

Tangudu CS, Charles J, Hurt SL, Dunphy BM, Smith RC, Bartholomay LC, Blitvich BJ. (2019) Skunk River virus, a novel orbivirus isolated from Aedes trivittatus in the United States. Journal of General Virology 100: 295-300. https://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.001219#tab2

Dunphy, B.M., Kovach, K.B., Gehrke, E.J., Field, E.N., Rowley, W.A., Bartholomay, L.C., Smith, R.C. (2019) Long-term surveillance defines spatial and temporal patterns implicating Culex tarsalis as the primary vector of West Nile virus. Scientific Reports 9(1):6637. https://www.nature.com/articles/s41598-019-43246-y

Kwon, H., Smith, R.C. (2019) Chemical depletion of phagocytic immune cells reveals dual roles of mosquito hemocytes in Anopheles gambiae anti-Plasmodium immunity. Proceedings of the National Academy of Sciences 116(28): 14119-14128. https://www.pnas.org/content/116/28/14119.long

Field, E.N., Tokarz, R.E., Smith, R.C. (2019) Satellite imaging and long-term mosquito surveillance implicate the influence of rapid urbanization on Culex vector populations. Insects 10(9), 269. https://www.mdpi.com/2075-4450/10/9/269

Hadfield, J., Brito, A.F., Swetnam, D.M., Vogels, C.B.F., Tokarz, R.E, Andersen, K.G., Smith, R.C., Bedford, T., Grubaugh, N.D. (2019) Twenty years of West Nile virus spread and evolution in the Americas visualized by Nextstrain. PloS Pathogens 15(10): e1008042. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008042

2018

Kovach, K.B., Smith, R.C. (2018) Surveillance of Mosquitoes (Diptera: Culicidae) in Southern Iowa, 2016. Journal of Medical Entomology 55:1341-1345. https://academic.oup.com/jme/advance-article/doi/10.1093/jme/tjy077/4999768

2017

Kwon, H., Arends, B.R., Smith, R.C. (2017) Late-phase immune responses limiting oocyst survival are independent of TEP1 function yet display strain specific differences in Anopheles gambiae. Parasites & Vectors 10:369. https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-017-2308-0

2016

Kwon, H., Agha, M.A., Smith, R.C., Nachman, R.J., Marion-Poll, F, Pietrantonio, P.V. (2016) A leucokinin mimetic elicits aversive behavior in mosquito Aedes aegypti (L.) and inhibits the sugar taste neuron.  Proceedings of the National Academy of Sciences 113(25): 6880-6885. http://www.pnas.org/content/113/25/6880

Orfano, A.S., Nacif-Pimenta, R., Duarte, A.P.M., Villegas, L.M., Rodrigues, N.B., Pinto, L.C., Campos, K.M.M., Pinilla, Y.T., Chaves, B., Barbosa Guerra, M.G.V., Monteiro, W.M., Smith, R.C., Molina-Cruz, A., Lacerda, M.V.G., Secundino, N.F.C., Jacobs-Lorena, M., Barillas-Mury, C., Pimenta, P.F.P. (2016) Species-specific escape of Plasmodium sporozoites from oocysts of avian, rodent, and human malarial parasites. Malaria Journal 15 (1), 394. https://malariajournal.biomedcentral.com/articles/10.1186/s12936-016-1451-y

Smith, R.C., King, J.G., Tao, D., Tomescu, O., Brando, C., Thallinger, G.G., Dinglasan R.R. (2016) Molecular profiling of phagocytic immune cells in Anopheles gambiae reveals integral roles for hemocytes in mosquito innate immunity. Molecular and Cellular Proteomics. 15: 3373-3387. http://www.mcponline.org/content/15/11/3373.abstract?sid=1f1b5387-e670-4255-989c-2d7d662c9765

Smith, R.C., Barillas-Mury, C. (2016) Plasmodium oocysts: overlooked targets of mosquito immunity. Trends in Parasitology 32 (12): 979-990.  http://www.cell.com/trends/parasitology/fulltext/S1471-4922(16)30142-8

2015

Smith, R.C., Jacobs-Lorena, M. (2015) Malaria parasite Pfs47 disrupts JNK signaling to escape mosquito immunity. Proceedings of the National Academy of Sciences 112(5): 1250-1. http://www.pnas.org/content/early/2015/01/21/1424227112.long

Smith, R.C., Barillas-Mury, C., Jacobs-Lorena, M. (2015) Hemocyte differentiation mediates the mosquito late-phase immune response against Plasmodium in Anopheles gambiae. Proceedings of the National Academy of Sciences 112(26): E3412-20. http://www.pnas.org/content/112/26/E3412

2014

Smith, R.C.*, Vega-Rodriguez, J.*, Jacobs-Lorena, M. (2014) The Plasmodium bottleneck: malaria parasite losses in the mosquito vector. Memorias do Instito Oswaldo Cruz 109(5): 644-661. http://memorias.ioc.fiocruz.br/issues/current-issue/item/1739-0597_the-plasmodium-bottleneck-malaria-parasite-losses-in-the-mosquito-vector

Smith, R.C., Colon-Lopez, D.D., Bosch, J. (2014) Immunization against a merozoite subtilisin protease attenuates Plasmodium infection in mice. Malaria Journal 13: 313. http://www.malariajournal.com/content/13/1/313

2013

Eappen, A.G.* Smith, R.C.*, Jacobs-Lorena, M. (2013) Enterobacter-activated mosquito immune responses to Plasmodium involve activation of SRPN6 in Anopheles stephensi. PLOS ONE 8(5): e62937. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0062937

Wright, J.A., Smith, R.C., Li, X., Craig, N.L., Atkinson, P.W. (2013) IPB7 transposase behavior in Drosophila melanogaster and Aedes aegypti. Insect Biochemistry and Molecular Biology 43(10):899-906. http://www.sciencedirect.com/science/article/pii/S096517481300115X

Smith, R.C., Kizito, C., Rasgon, J, Jacobs-Lorena, M. (2013) Transgenic mosquitoes expressing a phospholipase A2 gene have a fitness advantage when fed Plasmodium falciparum-infected blood. PLOS ONE 8(10): e76097. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0076097

2012

Smith, R.C., Eappen, A.G., Radtke, A.J., Jacobs-Lorena, M.  (2012) Regulation of anti-Plasmodium immunity by a LITAF-like transcription factor in the malaria vector Anopheles gambiae. PLOS Pathogens 8(10): e1002965. http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1002965

2011

Arensburger, P., Hice, R.H., Zhou, L., Smith, R.C., Tom, A.C., Wright, J.A., Knapp, J., O’Brochta, D.A., Craig, N.L., and Atkinson, P.W. (2011) Phylogenetic and functional characterization of the hAT transposon superfamily. Genetics 88(1): 45-57. http://www.genetics.org/content/188/1/45.long

Smith, R.C. and Atkinson, P.W. (2011) Mobility properties of the Hermes transposable element in transgenic lines of Aedes aegypti. Genetica 139(1): 7-22.  http://link.springer.com/article/10.1007%2Fs10709-010-9459-7

2010

Smith, R.C. and Jacobs-Lorena, M. Plasmodium-mosquito interactions: A tale of roadblocks and detours, In: Stephen J. Simpson, Editor(s), Advances in Insect Physiology, Academic Press, 2010, Volume 39, 119-149. http://www.sciencedirect.com/science/article/pii/B978012381387900004X

2007

Smith, R.C., Walter, M.F., Hice, R.H., O’Brochta, D.A., Atkinson, P.W. (2007) Testis-specific expression of the ß2 tubulin promoter of Aedes aegypti and its application as a genetic sex-separation marker.  Insect Molecular Biology 16(1): 61-71. http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2583.2006.00701.x/abstract