Publications

2025

Li, Y., Mei, Y., Schmidt-Danner, M.G., Lv, Y., Peters, R.J., Jia, M. (2025) “Pursuit of a hydroxylation switch uncovers a key residue for various product outcomes in the ent-kaurene synthase from Bradyrhizobium japonicum”, Org. Lett., 27(15):3942-3946. Google Scholar

Kudjordjie, E.N., Desmedt, W., Kyndt, T., Nicolaisen, M., Peters, R.J., Vestergård, M. (2025) “Diterpenoid phytoalexins shape rice root microbiomes and their association with root parasitic nematodes”, Environ. Microbiol., 27(4):e70084. Google Scholar

Raslan, A., Peters, R.J. (2025) “Exploring evolutionary use of single residue switches for alternative product outcome in class II diterpene cyclases”, Phytochemistry, 235:114459. Google Scholar

Peters, R.J., “Between scents and sterols: Cyclization of labdane-related diterpenes as model systems for enzymatic control of carbocation cascades”, J Biol Chem, vol. 301, art. 108142. Google Scholar

2024

Chen, X., Xu, M., Han, J., Schmidt-Dannert, M., Peters, R.J., Chen, F., “Discovery of bifunctional diterpene cyclases/synthases in bacteria supports a bacterial origin for the plant terpene synthase gene family”, Hortic Res, vol. 11, art. uhae221. Google Scholar

Feng, Y., Weers, T., Peters, R.J., “Double-barreled defense: Dual ent-miltiradiene synthases in most rice cultivars”, aBIOTECH, vol. 5, pp. 375-380. Google Scholar

Jin, B., Xu, K., Cui, G., Ma, Y., Yang, J., Chen, N., Zeng, T., Wang, J., Tian, M., Ma, Q., Zhang, H., Peters, R.J., Guo, J., Wu, R., Huang, L., “From functional plasticity of two diterpene synthases (IrKSL2/IrKSL3a) to enzyme evolution”, ACS Catal, vol. 14, pp. 2959-2970. Google Scholar

2023

Köllner, T.G., Gershenzon, J., Peters, R.J., Zerbe, P., Schmelz, E.A., “The terpene synthase gene family in maize – a clarification of existing community nomenclature”, BMC Genomics, vol. 24, art. 744. Google Scholar

Nagel, R., Alexander, L., Stewart, C.E., Peters, R.J., “Dual Factors Required for Cytochrome-P450 Mediated Ring Contraction in Bacterial Gibberellin Biosynthesis”, Proc Natl Acad Sci USA, vol. 120, art. e2221549120. Google Scholar

Wang, Z., Peters, R.J., “Dynamic evolution of terpenoid biosynthesis in the Lamiaceae”, Mol Plant, vol. 16, pp. 963-965. Google Scholar

Zhao, L., Oyagbenro, R., Xu, M., Peters, R.J., “Oryzalexin S biosynthesis: A cross-stitched disappearing pathway”, aBIOTECH, vol. 4, pp. 1-7. Google Scholar

Wang, Z., Nelson, D.R., Zhang, J., Wan, X., Peters, R.J., “Plant (di)terpenoid evolution: From pigments to hormones and beyond”, Nat Prod Rep, vol. 40, pp. 452-469. Google Scholar

2022

Lemke, C., Roach, K., Ortega, T., Tantillo, D.J., Siegel, J.B., Peters, R.J., “Investigation of acid-base catalysis in the halimadienyl diphosphate synthase involved in Mycobacterium tuberculosis virulence”, ACS Bio & Med Chem Au, vol. 2, pp. 490-498. Google Scholar

Desmedt, W., Kudjordjie, E.N., Chavan, S.N., Zhang, J., Li, R., Yang, B., Mori, M., Peters, R.J., Vanholme, B., Vestergård, M., Kyndt, T., “Rice diterpenoid phytoalexins are involved in defense against parasitic nematodes and shape rhizosphere nematode communities”, New Phytol, vol. 235, pp. 1231-1245. Google Scholar

Nett, R.S., Bender, K.S., Peters, R.J., “Production of the plant hormone gibberellin by rhizobia increases host legume nodule size”, ISME J, vol. 16, pp. 1809-1817. Google Scholar

Liang, J., Merrill, A.T., Laconsay, C.J., Hou, A., Pu, Q., Dickschat, J.S., Tantillo, D.J., Wang, Q., Peters, R.J., “Deceptive complexity in formation of cleistantha-8,12-diene”, Org Lett, vol. 24, pp. 2646-2649. Google Scholar

Jia, Q., Brown, R., Köllner, T.G., Fu, J., Chen, X., Wong, K.S.G., Gershenzon, J., Peters, R.J., Chen, F., “Origin and Early Evolution of the Plant Terpene Synthase Family”, Proc Natl Acad Sci USA, vol. 119, art. e2100361119. Google Scholar

Wang, J., Mao, Y., Ma, Y., Jin, B., Yang, J., Lin, H.X., Zeng, W., Zhao, Y., Gao, W., Peters, R.J., Guo, J., Cui, G., Huang, L., “Diterpene synthases from Leonurus japonicus elucidate epoxy-bridge formation of spiro-labdane diterpenoids”, Plant Physiol, vol. 189, pp. 99-111. Google Scholar

Wang, Z., Peters, R.J., “Tanshinones: Leading the way into Lamiaceae labdane-related diterpenoid biosynthesis”, Curr Opin Plant Biol, vol. 66, art. e102189. Google Scholar

Li, R., Zhang, J., Li, Z., Peters, R.J., Yang, B., “Dissecting the labdane-related diterpenoid biosynthetic gene clusters in rice reveals directional cross-cluster phytotoxicity”, New Phytol, vol. 233, pp. 878-889. Google Scholar

2021

Liang, J., An, T., Zhu, J.-X., Chen, S., Zhu, J.-H., Peters, R.J., Yu, R. Zi, J., “Mining of the Catharanthus roseus Genome Leads to Identification of a Biosynthetic Gene Cluster for Fungicidal Sesquiterpenes”, J Nat Prod, vol. 84, pp. 2709-2716. Google Scholar

Liang, J., Shen, Q., Wang, L., Liu, J., Fu, J., Zhao, L., Xu, M., Peters, R.J., Wang, Q., “Rice contains a biosynthetic gene cluster associated with production of the casbane-type diterpenoid phytoalexin ent-10-oxodepressin”, New Phytol, vol. 231, pp. 85-93. Google Scholar

Kitaoka, N., Zhang, J., Oyagbenro, R.K., Brown, B., Wu, Y., Yang, B., Li, Z., Peters, R.J., “Interdependent evolution of biosynthetic gene clusters for momilactone production in rice”, Plant Cell, vol. 33, pp. 290-305. Google Scholar

Brown, R., Jia, M., Peters, R.J., “A Pair of Threonines Mark ent-Kaurene Synthases for Phytohormone Biosynthesis”, Phytochemistry, vol. 185, art. 112672. Google Scholar

Zhang, J., Li, R., Xu, M., Hoffmann, R.I., Zhang, Y., Liu, B., Zhang, M., Yang, B., Li, Z., Peters, R.J., “A (Conditional) Role for Labdane-Related Diterpenoid Natural Products in Rice Stomatal Closure”, New Phytol, vol. 230, pp. 698-709. Google Scholar

Ma, Y., Cui, G., Chen, T., Ma, X., Wang, R., Jin, B., Yang, J. Kang, L., Tang, J., Lai, C., Wang, Y., Zhao, Y., Shen, Y., Zeng, W. Peters, R.J., Qi, X. Guo, J., Huang, L., “Expansion within the CYP71D subfamily in Salvia miltiorrhiza drove the heterocyclization that characterizes tanshinone biosynthesis”, Nat Commun, vol. 12, art. e685. Google Scholar

2020

Lemke, C., Whitham, O., Peters, R.J., “Magnesium-specific ring expansion/ contraction catalysed by the class II diterpene cyclase from pleuromutilin biosynthesis”, Org Biomol Chem, vol. 18, pp. 5586-5588. Google Scholar

Liang, J., Wang, L., Liu, J., Shen, Q., Fu, J., Peters, R.J., Wang, Q., “Probing enzymatic structure-function in the di-hydroxylating sesquiterpene synthase ZmEDS”, Biochemistry, vol. 59, pp. 2660-2666. Google Scholar

Zhang, J., Peters, R.J., “Why are momilactones always associated with biosynthetic gene clusters in plants?”, Proc Natl Acad Sci USA, vol. 117, pp. 13867-13869. Google Scholar

Nett, R.S., Nguyen, H., Nagel, R., Marcassa, A., Charles, T.C., Friedberg, I., Peters, R.J., “Unraveling a tangled skein: Evolutionary analysis of the bacterial gibberellin biosynthetic operon”, mSphere, vol. 5, art. e00292-20. Google Scholar

Peters, R.J., “Doing the gene shuffle to close synteny: Dynamic assembly of biosynthetic gene clusters”, New Phyto., vol. 227, pp. 992-994. Google Scholar

Pu, X., Tian, Y., Gao, R., Hao, L., Hu, Y., He, C. Xu, M., Peters, R.J., Xu, Z. Song, J., “The honeysuckle genome provides insight into the molecular mechanisms of carotenoid metabolism underlying dynamic flower coloration”, New Phytol, vol. 227, pp. 930-943. Google Scholar

Tu, L.-C., Su, P., Zhang, Z.-H., Gao, L.-H., Wang, J.-D., Hu, T.-Y., Zhou, J.-W., Zhang, Y.-F., Zhao, Y.-J., Liu, Y., Xong, Y.-D., Tong, Y.-R., Lu, Y., Yang, J., Xu, C., Jia, M., Peters, R.J., Huang, L., Gao, W., “Genome of Tripterygium wilfordii and identification of cytochrome P450 involved in triptolide biosynthesis”, Nat Commun, vol. 11, art. 971. Google Scholar

Zhang, J., Zhang, Y., Xing, J., Yu, H., Zhang, R., Tian, X., Duan, L., Zhang, M., Peters, R.J., Li, Z., “Introducing Selective Agrochemical Manipulation of Gibberellin Metabolism into a Cereal Crop”, Nat Plants, vol. 6, pp. 67-72. Google Scholar

2019

He, J., Chen, Q., Xin, P., Yuan, J., Ma, Y., Wang, X., Xu, M., Chu, J., Peters, R.J., Wang, G., “CYP72A Enzymes Catalyzing 13-Hydroxylation of Gibberellin are Indispensable for Primary Seed Dormancy in Brassicaceae Plants”, Nat Plants, vol. 5, pp. 1057-1065. Google Scholar

Lemke, C., Potter, K.C., Schulte, S., Peters, R.J., “Conserved bases for the initial cyclase in gibberellin phytohormone biosynthesis: from bacteria to plants”, Biochem J, vol. 476, pp. 2607-2621. Google Scholar

Jia, M., Zhang, Y., Siegel, J.B., Tantillo, D.J., Peters, R.J., “Switching on a Nontraditional Enzymatic Base – Deprotonation by Serine in the ent-Kaurene Synthase from Bradyrhizobium japonicum”, ACS Catal., vol. 9, pp. 8867-8871. Google Scholar

Huang, J., Zha, W., An, T., Dong, H., Huang, Y., Wang, D., Yu, R., Duan, L., Zhang, X., Peters, R.J., Dai, Z., Zi, J., “Identification of RoCYP01 (CYP716A155) enables construction of engineered yeast for high-yield production of betulinic acid”, Appl Microbiol Biotechnol, vol. 103, pp. 7029-7039. Google Scholar

Jia, M., Mishra, S.K., Tufts, S., Jernigan, R.L., Peters, R.J., “Combinatorial biosynthesis and the basis for substrate promiscuity in class I diterpene synthases”, Met Eng, vol. 55, pp. 44-58. Google Scholar

Sun, W., Leng, L., Yin, Q., Xu, M., Huang, M., Xu, Z., Zhang, Y., Wang, C., Xiong, C., Chen, S., Jiang, C., Xie, N., Song, C., Peters, R.J., Chen, S., “The genome of the medicinal plant Andrographis paniculata provides insight into biosynthesis of the bioactive diterpenoid neoandrographolide”, Plant J, vol. 97, pp. 841-857. Google Scholar

Nagel, R., Schmidt, A., Peters, R.J., “Isoprenyl diphosphate synthases, the chain length determining step in terpene biosynthesis”, Planta, vol. 249, pp. 9-20. Google Scholar

2018

Nagel, R., Bieber, J., Schmidt-Dannert, M.G., Nett, R.S., Peters, R.J., “A Third Class: Functional Gibberellin Biosynthetic Operon in Beta-Proteobacteria”, Front. Microbiol, vol. 9, art. 2916. Google Scholar

Nagel, R., Thomas, J.A., Adekunle, F.A., Mann, F.M., Peters, R.J., “Arginine in the FARM & SARM: A role in chain-length determination for arginine in the aspartate-rich motifs of isoprenyl diphosphate synthases from Mycobacterium tuberculosis”, Molecules, vol. 23, art. 2546. Google Scholar

Nagel, R., Peters, R.J., “Probing the specificity of CYP112 in bacterial gibberellin biosynthesis”, Biochem J, vol. 475, pp. 2167-2177. Google Scholar

Schulte, S., Potter, K.P., Lemke, C., Peters, R.J., “Catalytic bases and stereocontrol in Lamiaceae class II diterpene cyclases”, Biochemistry, vol. 57, pp. 3473-3479. Google Scholar

Lu, X., Zhang, J., Brown, B., Li, R., Rodríguez-Romero, J., Berasategui, A., Liu, B., Xu, M., Luo, D., Pan, Z., Baerson, S.R., Gershenzon, J., Li, Z., Sesma, A., Yang, B., Peters, R.J., “Inferring roles in defense from metabolic allocation with rice diterpenoids”, Plant Cell, vol. 30, pp. 1119-1131. Google Scholar

Liang, J., Liu, J., Jia, M., Brown, R., Zhou, K., Peters, R.J., Wang, Q., “Direct production of dihydroxylated sesquiterpenoids by a maize terpene synthase”, Plant J, vol. 94, pp. 847-856. Google Scholar

Nagel, R., Peters, R.J., “Diverging Mechanisms: Cytochrome-P450 Catalyzed Demethylation and g-Lactone Formation in Bacterial Gibberellin Biosynthesis”, Angew Chem Int Ed, vol. 57, pp. 6082-6085. Google Scholar

Jia, M., O’Brien, T.E., Zhang, Y., Siegel, J.B., Tantillo, D.J., Peters, R.J., “Changing face: A key residue for the addition of water by sclareol synthase”, ACS Catal, vol. 8, pp. 3133-3137. Google Scholar

Xu, M., Jia, M., Hong, Y.J., Yin, X., Tantillo, D.J., Proteau, P.J., Peters, R.J., “Premutilin synthase: Ring rearrangement by a class II diterpene cyclase”, Org Lett, vol. 20, pp. 1200-1202. Google Scholar

Su, P., Guan, H., Zhao, Y., Tong, Y., Xu, M., Zhang, Y., Hu, T., Yang, J., Cheng, Q., Gao, L., Liu, Y., Zhou, J., Peters, R.J., Huang, L., Gao, W., “Identification and functional characterization of diterpene synthases for triptolide biosynthesis from Tripterygium wilfordii”, Plant J, vol. 93, pp. 50-63. Google Scholar

2017

Nagel, R., Peters, R.J., “¹⁸O₂ labeling studies illuminate the oxidation of ent-kaurene in bacterial gibberellin biosynthesis”, Org Biomol Chem, vol. 15, pp. 7566-7571. Google Scholar

Inabuy, F.X., Fischedick, J.T., Lange, I., Hartmann, M., Srividya, N., Parrish, A.N., Xu, M., Peters, R.J., Lange, B.M., “Biosynthesis of diterpenoids in Tripterygium adventitious root cultures”, Plant Physiol, vol. 175, pp. 92-103. Google Scholar

Nagel, R., Peters, R.J., “Investigating the phylogenetic range of gibberellin biosynthesis in bacteria”, Mol Plant-Microbe Interact, vol. 30, pp. 343-349. Google Scholar

Nett, R.S., Contreras, T., Peters, R.J., “Characterization of CYP115 as a gibberellin 3-oxidase indicates that certain rhizobia can produce bioactive gibberellin A₄”, ACS Chem Biol, vol. 12, pp. 912-917. Google Scholar

Jia, M., Peters, R.J., “cis or trans with class II diterpene cyclases”, Org Biomol Chem, vol. 15, pp. 3158-3160. Google Scholar

Nagel, R., Turrini, P., Nett, R.S., Leach, J.E., Verdier, V., Van Sluys, M.-A., Peters, R.J., “An operon for production of bioactive gibberellin A₄ phytohormone with wide distribution in the bacterial rice leaf streak pathogen Xanthomonas oryzae pv. oryzicola”, New Phytol, vol. 214, pp. 1260-1266. Google Scholar

Jia, M., Zhou, K., Tufts, S., Schulte, S., Peters, R.J., “A pair of residues that interactively affect diterpene synthase product outcome”, ACS Chem Biol, vol. 12, pp. 862-867. Google Scholar

Xu, M., Hillwig, M.L., Tiernan, M.S., Peters, R.J., “Probing labdane-related diterpenoid biosynthesis in the fungal genus Aspergillus”, J Nat Prod, vol. 80, pp. 328-333. Google Scholar

Nett, R.S., Montanares, M., Marcassa, A., Lu, X., Nagel, R., Charles, T.C., Hedden, P., Rojas, M.C., Peters, R.J., “Elucidation of gibberellin biosynthesis in bacteria reveals convergent evolution”, Nat Chem Biol, vol. 13, pp. 69-74. Google Scholar

2016

Nett, R.S., Dickschat, J.S., Peters, R.J., “Labeling studies clarify the committed step in bacterial gibberellin biosynthesis”, Org Lett, vol. 18, pp. 5974-5977. Google Scholar

Jia, M., Peters, R.J., “Extending a single residue switch for abbreviating catalysis in plant ent-kaurene synthases”, Front Plant Sci, vol. 7, art. 1765. Google Scholar

Wang, Q., Jia, M., Huh, J.-H., Peters, R.J., Tholl, D., “Identification of a Dolabellane Type Diterpene Synthase and other Root-Expressed Diterpene Synthases in Arabidopsis”, Front Plant Sci, vol. 7, art. 1761. Google Scholar

Kumar, S., Kempinski, C., Zhuang, X., Norris, A., Mafu, S., Zi, J., Bell, S., Nybo, S., Kinison, S., Jiang, Z., Goklany, S., Linscott, K., Chen, X., Jia, Q., Brown, S., Bowman, J. Babbitt, P. Peters, R.J., Chen, F., Chappell, J., “Molecular Diversity of Terpene Synthases in the Liverwort Marchantia polymorpha”, Plant Cell, vol. 28, pp. 2632-2650. Google Scholar

Kitaoka, N., Wu, Y., Wang, Q., Zi, J., Peters, R.J., “Investigating inducible short-chain alcohol dehydrogenases/reductases clarifies rice oryzalexin biosynthesis”, Plant J, vol. 88, pp. 271-279. Google Scholar

Xu, H., Song, J., Luo, H., Li, Q., Zhu, Y., Xu, J., Li, Y., Song, C., Wang, B., Sun, W., Shen, G., Zhang, X., Qian, J., Zhang, Y., Ji, A., Xu, Z., Luo, X., He, L., Li, C., Sun, C., Yan, H., Cui, G., Li, X., Wei, J., Li, X., Liu, J., Wang, Y., Hayward, A., Nelson, D., Ning, Z., Peters, R.J., Qi, X., Chen, S., “Analysis of the genome sequence of the medicinal plant Salvia miltiorrhiza”, Mol Plant, vol. 9, pp. 949-952. Google Scholar

Jia, M., Potter, K.C., Peters, R.J., “Extreme promiscuity of a bacterial and a plant diterpene synthase enables combinatorial biosynthesis”, Met Eng, vol. 37, pp. 24-34. Google Scholar

Potter, K.C., Jia, M., Young, Y.J., Tantillo, D.J., Peters, R.J., “Product rearrangement from altering a single residue in the rice syn-copalyl diphosphate synthase”, Org Lett, vol. 18, pp. 1060-1063. Google Scholar

K. C. Potter, Zi, J., Hong, Y. J., Schulte, S., Malchow, B., Tantillo, D. J., and Peters, R. J., “Blocking Deprotonation with Retention of Aromaticity in a Plant ent-Copalyl Diphosphate Synthase Leads to Product Rearrangement”, Angew Chem Int Ed Eng, vol. 55, no. 2, pp. 634-638, 2016.

H. Mao, Liu, J., Ren, F., Peters, R. J., and Wang, Q., “Characterization of CYP71Z18 indicates a role in maize zealexin biosynthesis”, Phytochemistry, vol. 121, pp. 4-10, 2016.

J. Guo, Ma, X., Cai, Y., Ma, Y., Zhan, Z., Zhou, Y. J., Liu, W., Guan, M., Yang, J., Cui, G., Kang, L., Yang, L., Shen, Y., Tang, J., Lin, H., Ma, X., Jin, B., Liu, Z., Peters, R. J., Zhao, Z. K., and Huang, L., “Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones”, New Phytol, vol. 210, pp. 525-534, 2016.

S. Mafu, Jia, M., Zi, J., Xu, M., Morrone, D., Wu, Y., and Peters, R. J., “Probing the promiscuity of ent-kaurene oxidase via combinatorial biosynthesis”, Proc Natl Acad Sci U S A, vol. 113, pp. 2526-2531, 2016. Google Scholar

J. Fu, Ren, F., Lu, X., Mao, H., Xu, M., Degenhardt, J., Peters, R. J., and Wang, Q., “A tandem array of ent-kaurene synthases in maize with roles in gibberellin and more specialized metabolism”, Plant Physiol, vol. 170, pp. 742-751, 2016.

2015

N. Kitaoka, Lu, X., Yang, B., and Peters, R. J., “The application of synthetic biology to elucidation of plant mono-, sesqui-, and diterpenoid metabolism”, Mol Plant, vol. 8, pp. 6-16, 2015. Google Scholar

Y. Matsuba, Zi, J., Jones, A. D., Peters, R. J., and Pichersky, E., “Biosynthesis of the Diterpenoid Lycosantalonol via Nerylneryl Diphosphate in Solanum lycopersicum”, PLoS One, vol. 10, p. e0119302, 2015.

S. Mafu, Potter, K. C., Hillwig, M. L., Schulte, S., Criswell, J., and Peters, R. J., “Efficient heterocyclisation by (di)terpene synthases”, Chem Commun (Camb), vol. 51, no. 70, pp. 13485-7, 2015. Google Scholar

X. Lu, Hershey, D. M., Wang, L., Bogdanove, A. J., and Peters, R. J., “An ent-kaurene-derived diterpenoid virulence factor from Xanthomonas oryzae pv. oryzicola”, New Phytol, vol. 206, pp. 295-302, 2015.

Z. Xu, Peters, R. J., Weirather, J., Luo, H., Liao, B., Zhang, X., Zhu, Y., Ji, A., Zhang, B., Hu, S., Au, K. F., Song, J., and Chen, S., “Full-length transcriptome sequences and splice variants obtained by a combination of sequencing platforms applied to different root tissues of Salvia miltiorrhiza and tanshinone biosynthesis”, Plant J, vol. 82, pp. 951-61, 2015. Google Scholar

G. Cui, Duan, L., Jin, B., Qian, J., Xue, Z., Shen, G., Snyder, J. H., Song, J., Chen, S., Huang, L., Peters, R. J., and Qi, X., “Funcation divergence of diterpene synthases in the medicinal plant Salvia miltiorrhiza Bunge”, Plant Physiol, vol. 169, pp. 1607-1618, 2015. Google Scholar

A. M. Boutanaev, Moses, T., Zi, J., Nelson, D. R., Mugford, S. T., Peters, R. J., and Osbourn, A., “Investigation of terpene diversification across multiple sequenced plant genomes”, Proc Natl Acad Sci U S A, vol. 112, pp. E81-8, 2015. Google Scholar

A. T. Klein, Yagnik, G. B., Hohenstein, J. D., Ji, Z., Zi, J., Reichert, M. D., MacIntosh, G. C., Yang, B., Peters, R. J., Vela, J., and Lee, Y. J., “Investigation of the Chemical Interface in the Soybean-Aphid and Rice-Bacteria Interactions Using MALDI-Mass Spectrometry Imaging”, Anal Chem, vol. 87, no. 10, pp. 5294-5301, 2015. Google Scholar

N. Kitaoka, Wu, Y., Xu, M., and Peters, R. J., “Optimization of recombinant expression enables discovery of novel cytochrome P450 activity in rice diterpenoid biosynthesis”, Appl Microbiol Biotechnol, vol. 99, no. 18, 2015. Google Scholar

2014

M. Köksal, Potter, K., Peters, R. J., and Christianson, D. W., “1.55 Å-resolution structure of ent-copalyl diphosphate synthase and exploration of general acid function by site-directed mutagenesis”, Biochimica et Biophysica Acta (BBA), vol. 1840, no. 1, pp. 184-190, 2014. Google Scholar

A. J. Jackson, Hershey, D. M., Chesnut, T., Xu, M., and Peters, R. J., “Biochemical characterization of the castor bean ent-kaurene synthase(-like) family supports quantum chemical view of diterpene cyclization”, Phytochemistry, vol. 103, pp. 13-21, 2014.

E. A. Schmelz, Huffaker, A., Sims, J. W., Christensen, S. A., Lu, X., Okada, K., and Peters, R. J., “Biosynthesis, elicitation and roles of monocot terpenoid phytoalexins”, The Plant Journal, vol. 79, no. 4, pp. 659-678, 2014.

J. Zi, Matsuba, Y., Hong, Y. J., Jackson, A. J., Tantillo, D. J., Pichersky, E., and Peters, R. J., “Biosynthesis of lycosantalonol, a cis-prenyl derived diterpenoid”, J Am Chem Soc, vol. 136, pp. 16951-3, 2014.

M. Xu, Hillwig, M. L., Lane, A. L., Tiernan, M. S., Moore, B. S., and Peters, R. J., “Characterization of an Orphan Diterpenoid Biosynthetic Operon from Salinispora arenicola”, Journal of natural products, vol. 77, no. 9, pp. 2144-2147, 2014.

W. Gao, Sun, H. - X., Xiao, H., Cui, G., Hillwig, M. L., Jackson, A., Wang, X., Shen, Y., Zhao, N., and Zhang, L., “Combining metabolomics and transcriptomics to characterize tanshinone biosynthesis in Salvia miltiorrhiza”, BMC genomics, vol. 15, no. 1, p. 73, 2014.

D. M. Hershey, Lu, X., Zi, J., and Peters, R. J., “Functional conservation of the capacity for ent-kaurene biosynthesis and an associated operon in certain rhizobia”, Journal of bacteriology, vol. 196, no. 1, pp. 100-106, 2014. Google Scholar

K. Potter, Criswell, J., Zi, J., Stubbs, A., and Peters, R. J., “Novel Product Chemistry from Mechanistic Analysis of ent‐Copalyl Diphosphate Synthases from Plant Hormone Biosynthesis”, Angewandte Chemie International Edition, vol. 53, pp. 7198-7202, 2014. Google Scholar

J. Zi, Mafu, S., and Peters, R. J., “To Gibberellins and Beyond! Surveying the Evolution of (Di)Terpenoid Metabolism”, Annual review of plant biology, vol. 65, pp. 259-286, 2014. Google Scholar

2013

J. Zi and Peters, R. J., “Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae”, Organic & biomolecular chemistry, vol. 11, no. 44, pp. 7650-7652, 2013.

J. Guo, Zhou, Y. J., Hillwig, M. L., Shen, Y., Yang, L., Wang, Y., Zhang, X., Liu, W., Peters, R. J., and Chen, X., “CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts”, Proceedings of the National Academy of Sciences, vol. 110, no. 29, pp. 12108-12113, 2013.

R. J. Peters, “Gibberellin phytohormone metabolism”, in Isoprenoid Synthesis in Plants and Microorganisms, Springer New York, 2013, pp. 233-249. Google Scholar

W. Yisheng, Qiang, W., L Matthew, H., and J Reuben, P., “Picking sides: distinct roles for CYP76M6 and CYP76M8 in rice oryzalexin biosynthesis”, Biochemical Journal, vol. 454, no. 2, pp. 209-216, 2013. Google Scholar

H. Kato-Noguchi and Peters, R. J., “The role of momilactones in rice allelopathy”, Journal of chemical ecology, vol. 39, no. 2, pp. 175-185, 2013. Google Scholar

2012

Q. Wang, Hillwig, M. L., Okada, K., Yamazaki, K., Wu, Y., Swaminathan, S., Yamane, H., and Peters, R. J., “Characterization of CYP76M5–8 indicates metabolic plasticity within a plant biosynthetic gene cluster”, Journal of Biological Chemistry, vol. 287, no. 9, pp. 6159-6168, 2012.

Q. Wang, Hillwig, M. L., Wu, Y., and Peters, R. J., “CYP701A8: a rice ent-kaurene oxidase paralog diverted to more specialized diterpenoid metabolism”, Plant physiology, vol. 158, no. 3, pp. 1418-1425, 2012.

L. Zu, Xu, M., Lodewyk, M. W., Cane, D. E., Peters, R. J., and Tantillo, D. J., “Effect of isotopically sensitive branching on product distribution for pentalenene synthase: support for a mechanism predicted by quantum chemistry”, Journal of the American Chemical Society, vol. 134, no. 28, pp. 11369-11371, 2012. Google Scholar

F. M. Mann, Xu, M., Davenport, E. K., and Peters, R. J., “Functional characterization and evolution of the isotuberculosinol operon in Mycobacterium tuberculosis and related Mycobacteria”, Frontiers in microbiology, vol. 3, 2012. Google Scholar

Y. Wu, Zhou, K., Toyomasu, T., Sugawara, C., Oku, M., Abe, S., Usui, M., Mitsuhashi, W., Chono, M., and Chandler, P. M., “Functional characterization of wheat copalyl diphosphate synthases sheds light on the early evolution of labdane-related diterpenoid metabolism in the cereals”, Phytochemistry, vol. 84, pp. 40-46, 2012. Google Scholar

K. Zhou, Xu, M., Tiernan, M., Xie, Q., Toyomasu, T., Sugawara, C., Oku, M., Usui, M., Mitsuhashi, W., and Chono, M., “Functional characterization of wheat ent-kaurene(-like) synthases indicates continuing evolution of labdane-related diterpenoid metabolism in the cereals”, Phytochemistry, vol. 84, pp. 47-55, 2012. Google Scholar

M. Xu, Galhano, R., Wiemann, P., Bueno, E., Tiernan, M., Wu, W., Chung, I. ‐M., Gershenzon, J., Tudzynski, B., and Sesma, A., “Genetic evidence for natural product‐mediated plant–plant allelopathy in rice (Oryza sativa)”, New Phytologist, vol. 193, no. 3, pp. 570-575, 2012. Google Scholar

K. Zhou, Gao, Y., Hoy, J. A., Mann, F. M., Honzatko, R. B., and Peters, R. J., “Insights into diterpene cyclization from structure of bifunctional abietadiene synthase from Abies grandis”, Journal of Biological Chemistry, vol. 287, no. 9, pp. 6840-6850, 2012. Google Scholar

F. M. Mann and Peters, R. J., “Isotuberculosinol: the unusual case of an immunomodulatory diterpenoid from Mycobacterium tuberculosis”, Med. Chem. Commun., vol. 3, no. 8, pp. 899-904, 2012. Google Scholar

J. Criswell, Potter, K., Shephard, F., Beale, M. H., and Peters, R. J., “A single residue change leads to a hydroxylated product from the class II diterpene cyclization catalyzed by abietadiene synthase”, Organic letters, vol. 14, no. 23, pp. 5828-5831, 2012.

Y. Gao, Honzatko, R. B., and Peters, R. J., “Terpenoid synthase structures: a so far incomplete view of complex catalysis”, Natural product reports, vol. 29, no. 10, pp. 1153-1175, 2012. Google Scholar

2011

Q. Wang, Hillwig, M. L., and Peters, R. J., “CYP99A3: functional identification of a diterpene oxidase from the momilactone biosynthetic gene cluster in rice”, The Plant Journal, vol. 65, no. 1, pp. 87-95, 2011.

M. L. Hillwig, Mann, F. M., and Peters, R. J., “Diterpenoid biopolymers: new directions for renewable materials engineering”, Biopolymers, vol. 95, no. 2, pp. 71-76, 2011. Google Scholar

M. L. Hillwig, Xu, M., Toyomasu, T., Tiernan, M. S., Wei, G., Cui, G., Huang, L., and Peters, R. J., “Domain loss has independently occurred multiple times in plant terpene synthase evolution”, The Plant Journal, vol. 68, no. 6, pp. 1051-1060, 2011. Google Scholar

K. Zhou and Peters, R. J., “Electrostatic effects on (di)terpene synthase product outcome”, Chemical Communications, vol. 47, no. 14, pp. 4074-4080, 2011. Google Scholar

D. Morrone, Hillwig, M., Mead, M., Lowry, L., Fulton, D., and Peters, R., “Evident and latent plasticity across the rice diterpene synthase family with potential implications for the evolution of diterpenoid metabolism in the cereals”, Biochem. J, vol. 435, pp. 589-595, 2011. Google Scholar

F. M. Mann, VanderVen, B. C., and Peters, R. J., “Magnesium depletion triggers production of an immune modulating diterpenoid in Mycobacterium tuberculosis”, Molecular microbiology, vol. 79, no. 6, pp. 1594-1601, 2011. Google Scholar

S. Mafu, Hillwig, M. L., and Peters, R. J., “A Novel Labda‐7,13E‐dien‐15‐ol‐Producing Bifunctional Diterpene Synthase from Selaginella moellendorffii”, ChemBioChem, vol. 12, no. 13, pp. 1984-1987, 2011.

Y. Wu, Hillwig, M. L., Wang, Q., and Peters, R. J., “Parsing a multifunctional biosynthetic gene cluster from rice: Biochemical characterization of CYP71Z6 & 7”, FEBS letters, vol. 585, no. 21, pp. 3446-3451, 2011. Google Scholar

F. M. Mann, Thomas, J. A., and Peters, R. J., “Rv0989c encodes a novel (E)-geranyl diphosphate synthase facilitating decaprenyl diphosphate biosynthesis in Mycobacterium tuberculosis”, FEBS letters, vol. 585, no. 3, pp. 549-554, 2011. Google Scholar

M. Köksal, Hu, H., Coates, R. M., Peters, R. J., and Christianson, D. W., “Structure and mechanism of the diterpene cyclase ent-copalyl diphosphate synthase”, Nature chemical biology, vol. 7, no. 7, pp. 431-433, 2011. Google Scholar

2010

D. Morrone, Chen, X., Coates, R., and Peters, R., “Characterization of the kaurene oxidase CYP701A3, a multifunctional cytochrome P450 from gibberellin biosynthesis”, Biochem. J, vol. 431, pp. 337-344, 2010.

R. Cao, Zhang, Y., Mann, F. M., Huang, C., Mukkamala, D., Hudock, M. P., Mead, M. E., Prisic, S., Wang, K., and Lin, F. ‐Y., “Diterpene cyclases and the nature of the isoprene fold”, Proteins: Structure, Function, and Bioinformatics, vol. 78, no. 11, pp. 2417-2432, 2010. Google Scholar

D. Morrone, Lowry, L., Determan, M. K., Hershey, D. M., Xu, M., and Peters, R. J., “Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering”, Applied microbiology and biotechnology, vol. 85, no. 6, pp. 1893-1906, 2010. Google Scholar

F. M. Mann, Prisic, S., Davenport, E. K., Determan, M. K., Coates, R. M., and Peters, R. J., “A single residue switch for Mg2+-dependent inhibition characterizes plant class II diterpene cyclases from primary and secondary metabolism”, Journal of Biological Chemistry, vol. 285, no. 27, pp. 20558-20563, 2010.

N. Maugel, Mann, F. M., Hillwig, M. L., Peters, R. J., and Snider, B. B., “Synthesis of (±)-Nosyberkol (Isotuberculosinol, Revised Structure of Edaxadiene) and (±)-Tuberculosinol”, Organic letters, vol. 12, no. 11, pp. 2626-2629, 2010. Google Scholar

R. J. Peters, “Two rings in them all: the labdane-related diterpenoids”, Natural product reports, vol. 27, no. 11, pp. 1521-1530, 2010. Google Scholar

2009

F. M. Mann, Prisic, S., Hu, H., Xu, M., Coates, R. M., and Peters, R. J., “Characterization and Inhibition of a Class II Diterpene Cyclase from Mycobacterium tuberculosis IMPLICATIONS FOR TUBERCULOSIS”, Journal of Biological Chemistry, vol. 284, no. 35, pp. 23574-23579, 2009

S. Swaminathan, Morrone, D., Wang, Q., D Fulton, B., and Peters, R. J., “CYP76M7 is an ent-cassadiene C11α-hydroxylase defining a second multifunctional diterpenoid biosynthetic gene cluster in rice”, The Plant Cell Online, vol. 21, no. 10, pp. 3315-3325, 2009.

F. M. Mann, Xu, M., Chen, X., D Fulton, B., Russell, D. G., and Peters, R. J., “Edaxadiene: a new bioactive diterpene from Mycobacterium tuberculosis”, Journal of the American Chemical Society, vol. 131, no. 48, pp. 17526-17527, 2009. Google Scholar

W. Gao, Hillwig, M. L., Huang, L., Cui, G., Wang, X., Kong, J., Yang, B., and Peters, R. J., “A functional genomics approach to tanshinone biosynthesis provides stereochemical insights”, Organic letters, vol. 11, no. 22, pp. 5170-5173, 2009.

D. Morrone, Chambers, J., Lowry, L., Kim, G., Anterola, A., Bender, K., and Peters, R. J., “Gibberellin biosynthesis in bacteria: Separate ent-copalyl diphosphate and ent-kaurene synthases in Bradyrhizobium japonicum”, FEBS letters, vol. 583, no. 2, pp. 475-480, 2009. Google Scholar

K. Zhou and Peters, R. J., “Investigating the conservation pattern of a putative second terpene synthase divalent metal binding motif in plants”, Phytochemistry, vol. 70, no. 3, pp. 366-369, 2009. Google Scholar

2008

D. Morrone, Xu, M., D Fulton, B., Determan, M. K., and Peters, R. J., “Increasing complexity of a diterpene synthase reaction with a single residue switch”, Journal of the American Chemical Society, vol. 130, no. 16, pp. 5400-5401, 2008. Google Scholar

2007

A. Roy, Roberts, F. G., P Wilderman, R., Zhou, K., Peters, R. J., and Coates, R. M., “16-Aza-ent-beyerane and 16-Aza-ent-trachylobane: potent mechanism-based inhibitors of recombinant ent-kaurene synthase from Arabidopsis thaliana”, Journal of the American Chemical Society, vol. 129, no. 41, pp. 12453-12460, 2007.

M. Xu, P Wilderman, R., and Peters, R. J., “Following evolution's lead to a single residue switch for diterpene synthase product outcome”, Proceedings of the National Academy of Sciences, vol. 104, no. 18, pp. 7397-7401, 2007. Google Scholar

M. Xu, P Wilderman, R., Morrone, D., Xu, J., Roy, A., Margis-Pinheiro, M., Upadhyaya, N. M., Coates, R. M., and Peters, R. J., “Functional characterization of the rice kaurene synthase-like gene family”, Phytochemistry, vol. 68, no. 3, pp. 312-326, 2007. Google Scholar

A. Cyr, P Wilderman, R., Determan, M., and Peters, R. J., “A modular approach for facile biosynthesis of labdane-related diterpenes”, Journal of the American Chemical Society, vol. 129, no. 21, pp. 6684-6685, 2007.

S. Prisic, Xu, J., Coates, R. M., and Peters, R. J., “Probing the role of the DXDD motif in class II diterpene cyclases”, ChemBioChem, vol. 8, no. 8, pp. 869-874, 2007. Google Scholar

R. P Wilderman and Peters, R. J., “A single residue switch converts abietadiene synthase into a pimaradiene specific cyclase”, Journal of the American Chemical Society, vol. 129, no. 51, pp. 15736-15737, 2007.

S. Prisic and Peters, R. J., “Synergistic substrate inhibition of ent-copalyl diphosphate synthase: a potential feed-forward inhibition mechanism limiting gibberellin metabolism”, Plant physiology, vol. 144, no. 1, pp. 445-454, 2007. Google Scholar

2006

R. J. Peters, “Uncovering the complex metabolic network underlying diterpenoid phytoalexin biosynthesis in rice and other cereal crop plants”, Phytochemistry, vol. 67, no. 21, pp. 2307-2317, 2006. Google Scholar

D. Morrone, Jin, Y., Xu, M., Choi, S. - Y., Coates, R. M., and Peters, R. J., “An unexpected diterpene cyclase from rice: functional identification of a stemodene synthase”, Archives of biochemistry and biophysics, vol. 448, no. 1, pp. 133-140, 2006.

2005

L. J. Harris, Saparno, A., Johnston, A., Prisic, S., Xu, M., Allard, S., Kathiresan, A., Ouellet, T., and Peters, R. J., “The maize An2 gene is induced by Fusarium attack and encodes an ent-copalyl diphosphate synthase”, Plant molecular biology, vol. 59, no. 6, pp. 881-894, 2005. Google Scholar

2004

M. Xu, Hillwig, M. L., Prisic, S., Coates, R. M., and Peters, R. J., “Functional identification of rice syn‐copalyl diphosphate synthase and its role in initiating biosynthesis of diterpenoid phytoalexin/allelopathic natural products”, The Plant Journal, vol. 39, no. 3, pp. 309-318, 2004. Google Scholar

R. P Wilderman, Xu, M., Jin, Y., Coates, R. M., and Peters, R. J., “Identification of syn-pimara-7,15-diene synthase reveals functional clustering of terpene synthases involved in rice phytoalexin/allelochemical biosynthesis”, Plant physiology, vol. 135, no. 4, pp. 2098-2105, 2004. Google Scholar

R. J. Peters and Croteau, R. B., “Metabolic engineering of plant secondary metabolism”, Handbook of plant biotechnology, 2004. Google Scholar

S. Prisic, Xu, M., P Wilderman, R., and Peters, R. J., “Rice contains two disparate ent-copalyl diphosphate synthases with distinct metabolic functions”, Plant physiology, vol. 136, no. 4, pp. 4228-4236, 2004. Google Scholar

2003

R. J. Peters and Croteau, R. B., “Alternative termination chemistries utilized by monoterpene cyclases: chimeric analysis of bornyl diphosphate, 1,8-cineole, and sabinene synthases”, Archives of biochemistry and biophysics, vol. 417, no. 2, pp. 203-211, 2003.

R. J. Peters, Carter, O. A., Zhang, Y., Matthews, B. W., and Croteau, R. B., “Bifunctional abietadiene synthase: mutual structural dependence of the active sites for protonation-initiated and ionization-initiated cyclizations”, Biochemistry, vol. 42, no. 9, pp. 2700-2707, 2003.

O. A. Carter, Peters, R. J., and Croteau, R., “Monoterpene biosynthesis pathway construction in Escherichia coli”, Phytochemistry, vol. 64, no. 2, pp. 425-433, 2003. Google Scholar

1999

E. D Anderson, Peters, R. J., Wilk, B., and Agard, D. A., “α-Lytic protease precursor: Characterization of a structured folding intermediate”, Biochemistry, vol. 38, no. 15, pp. 4728-4735, 1999.

1998

R. J. Peters, Shiau, A. K., Sohl, J. L., D Anderson, E., Tang, G., Silen, J. L., and Agard, D. A., “Pro region C-terminus: protease active site interactions are critical in catalyzing the folding of α-lytic protease”, Biochemistry, vol. 37, no. 35, pp. 12058-12067, 1998. Google Scholar

1997

L. D. Hernandez, Peters, R. J., Delos, S. E., Young, J. A. T., Agard, D. A., and White, J. M., “Activation of a retroviral membrane fusion protein: soluble receptor-induced liposome binding of the ALSV envelope glycoprotein”, The Journal of cell biology, vol. 139, no. 6, pp. 1455-1464, 1997.

1995

K. Zingler, Bélanger, Ca, Peters, R., Agard, E., and Young, J. A., “Identification and characterization of the viral interaction determinant of the subgroup A avian leukosis virus receptor.”, Journal of virology, vol. 69, no. 7, pp. 4261-4266, 1995. Google Scholar