Research

Publications 

  1. Goebel, K, Musser ML, Pieper J. Carbon dioxide laser ablation as an alternative or adjunct treatment of Bowenoid in situ carcinoma (BISC) in five cats. The Journal of Feline Medicine and Surgery. Epub February 2026. [journal link]
  2. Musser ML, Doke RN, Phillips RL, Viall AK, Johannes CM. High expression of prostaglandin EP4 receptor mRNA in feline head and neck squamous cell carcinoma. Canadian Journal of Veterinary Research. (89)3: 113. July 2025. [journal link]
  3. Konstantinidis AO, Adamama-Moraitou KK, Griggs A, Musser ML, Nenninger AS, Soubasis N, Pardali D, Mylonakis ME, Jergens AE. Blood Leukocyte Ratios as Predictive Markers of Chronic Enteropathy Phenotypes in Cats. Veterinary Sciences. 12: 613. June 2025. [journal link]
  4. Musser ML, Choi E, Viall AK, Meritet D, Matthews KG. Prognostic Impact of a Histologic Grading Scheme in Dogs Diagnosed With Rib Chondrosarcoma. Veterinary and Comparative Oncology. November 2024 [journal link]
  5. Musser ML, Jones PD, Goodson, TL, Roof E, Johannes CM. Response to tigilanol tiglate in dogs with mast cell tumors. Journal of Veterinary Internal Medicine. October 2024. [journal link]
  6. Ortiz CR, Musser ML, Yuan L, Mochel J, Talbott J, Johannes CM, Berger EP. Retrospective evaluation of toceranib phosphate (Palladia) use in the treatment of feline pancreatic carcinoma. The Canadian Veterinary Journal. 64(12), December 2023. [journal link]
  7. Musser ML, Coto GM, Lingnan Y, Mochel JP, Johannes CM. Pilot safety evaluation of doxorubicin chemotherapy combined with non-specific immunotherapy (Immunocidin®) for canine splenic hemangiosarcoma. PLOS ONE. December 2022. [journal link]
  8. Musser ML, Clifford CA, Bergman PJ, Treml LS, McAnulty LC, McNiel EA, Johannes CM. Randomized trial evaluating chemotherapy alone or chemotherapy and a novel monoclonal antibody for canine T-cell lymphoma: a multi-centre US study. VetRecord Open. November 2022. [journal link]
  9. Musser ML. The role of glucocorticoids and NSAIDs in cancer treatment for dogs and cats. Invited monograph, Today's Veterinary Practice. May/June 2022. [journal link]
  10. Lawson H, Musser ML, Regan R, Moore A, Hohenhaus A, Flesner B, Johannes CM. Toxicity, outcome, and management of anthracycline overdoses in 16 dogs. Journal of Veterinary Internal Medicine. November 2021. [journal link]
  11. Musser ML, Curran K, Flesner B, Johannes CM. A retrospective evaluation of chemotherapy overdoses in dogs and cats, Frontiers in Veterinary Science, 8: 1087. September 2021. [journal link]
  12. Musser ML, Johannes CM. Toceranib phosphate (Palladia) for the treatment of canine exocrine pancreatic adenocarcinoma. BMC Veterinary Research, 17: 269. August 2021. [journal link]
  13. Musser ML, Viall AV, Phillips RL, Fasina O, Johannes CM. Prostaglandin EP4 receptor mRNA expression in canine lymphoma. Veterinary and Comparative Oncology. Epub July 2021. [journal link]
  14. Rassnick KM, Bailey DB, Kamstock DA, LeBlanc CJ, Berger EP, Flory AB, Kiselow MA, Intile JL, Malone EK, Regan RC, Musser ML, Yanda N, Johannes CM. Survival time for dogs with previously untreated, peripheral nodal, intermediate- or large-cell lymphoma treated with prednisone alone: the Canine Lymphoma Steroid Only trial. J Am Vet Med Assoc, 259 (1): 62. July 2021. [journal link]
  15. Musser ML, Berger EP, Tripp CD, Clifford CA, Bergman PJ, Johannes CM. Safety evaluation of the canine osteosarcoma vaccine, live Listeria vector. Veterinary and Comparative Oncology. Epub July 2020. 19 (1): 92. March 2021. [journal link]
  16. Musser ML. Lipoma and Liposarcoma (Tumors of Adipose Tissue). Plumb's Pro. Invited monograph. March 2021.
  17. Coto GM, Musser ML, Tropf M, Ward JL, Seo Y, Mochel JP, Johannes CM. A multi-institutional retrospective analysis of toceranib phosphate for presumed or confirmed canine aortic body chemodectomas. Frontiers in Veterinary Science. February 2021. [journal link].
  18. Minkler S, Lucien F, Kimber MJ, Sahoo D, Bourgois-Mochel A, Musser ML, Johannes, CM, Frank I, Cheville J, Allenspach K, Mochel JP. Emerging roles of urine-derived components for the management of bladder cancer: One man’s trash is another man’s treasure. Cancers. 13 (3): 422. January 2021. [journal link].
  19. Musser ML, Viall AK, Phillips RL, Hostetter JM, Johannes CM. Analysis of prostaglandin EP4 receptor gene expression in canine osteosarcoma. Can J Vet Res. 85: 1. January 2021. [journal link]
  20. Johannes CM, Heinrich E, Musser ML, Andreasen C. Hypercalcemia of malignancy associated with exocrine pancreatic adenocarcinoma in a dog. Veterinary Record Case Reports 8: e001190. October 2020. [journal link]
  21. Musser ML, Viall AK, Phillips RL, Hostetter JH, Johannes CM. Gene expression of prostaglandin EP4 receptor in three canine carcinomas. BMC Veterinary Research. 16: 213. June 2020. [journal link]
  22. Musser ML, Berger EP, Parsons C, Kathariou S, Johannes, CM. Vaccine strain Listeria monocytogenes abscess in a dog: a case report. BMC Veterinary Research. 15 (1), 467. December 2019. [journal link]
  23. Musser ML, Mahaffey AL Fath MA, Buettner GR, Wagner BA, Schneider BK, Seo Y, Mochel JP, Johannes CM. In vitro Cytotoxicity and Pharmacokinetic Evaluation of Pharmacological Ascorbate in Dogs. Frontiers in Veterinary Science. 6, 385. November 2019. [journal link]
  24. Johannes CM, Musser ML. Anorexia and the cancer patient. Veterinary Clinics of North America: Small Animal Practice. 49 (5): 837-854. September 2019. [journal link]
  25. Johannes CM, Musser ML. The use of capromorelin for the clinical problem of inappetence. Today’s Veterinary Practice. 9 (4): 70-74. July/August 2019. [journal link]
  26. Wehrman R, Sebbag L, Reilly C, Allbaugh R, Ben-Shlomo G, Berger E, Musser M. Richter’s syndrome as an ocular manifestation of systemic disease in a dog. Journal of Veterinary Medicine and Surgery. 2 (1):22. February 2019. [journal link]
  27. Berger E, Johannes C, Jergens A, Allenspach K, Powers B, Du Y, Mochel J, Fox L, Musser M. Retrospective evaluation of toceranib phosphate (Palladia®) use in the treatment of canine gastrointestinal stromal tumors. Journal of Veterinary Internal Medicine. 1-9. October 2018. [journal link]
  28. Musser ML, Taikowski KL, Johannes CM, Bergman PJ. Retrospective evaluation of toceranib phosphate (Palladia®) use in the treatment of inoperable, metastatic, or recurrent canine pheochromocytomas: 5 cases (2014-2017). BMC Veterinary Research. 14 (1): 272. September 2018. [journal link]
  29. Musser ML, Toone KE, Berger EP, Viall AK, Fox LE, Johannes CM. Selective dysmegakaryocytopoiesis secondary to chemotherapy in a dog with lymphoblastic lymphoma: A Case Report. Journal of Veterinary Medicine and Surgery. 2 (1): 21. July 2018. [journal link]
  30. Musser ML, Berger EP, Flaherty H, Fox LE, Johannes CM. Marked paraneoplastic hypereosinophilia associated with a low grade, metastatic canine mast cell tumor. Veterinary Record Case Reports 6: e000563. June 2018. [journal link]
  31. Meichner K, Musser M, Grindem, C. What is your diagnosis? Urine crystals in a dog. Veterinary Clinical Pathology. 44 (4):613-614. December, 2015.* [journal link]
  32. Musser ML, Quinn HT and Chretin JD. Low apparent risk of CCNU (lomustine)-associated clinical hepatotoxicity in cats. Journal of Feline Medicine and Surgery. 14 (12):871-875. December, 2012.* [journal link]
  33. Rankin EB, Fuh KC, Taylor TE, Krieg AJ, Musser M, Yuan J, Wei K, Kuo CJ, Longacre TA and Giaccia AJ. AXL is an essential factor and therapeutic target for metastatic ovarian cancer. Cancer Research. 70 (19):7570-7579. October, 2010.* [journal link]

*Denotes prior to ISU appointment.

Abstract Presentations 

  1. Evaluation of High-Dose Ascorbate Combined with Amputation and Carboplatin for Canine Osteosarcoma (OSA). Margaret Musser (Presenter), Benjamin J. Miller, Keiko Murakami, Chad M. Johannes. Veterinary Cancer Society Annual Conference, Orlando, FL. October 2024. (Poster)
  2. Investigation of Different Leukocyte Ratios as Diagnostic Markers in Cats with Chronic Enteropathy. Alexandros O. Konstantinidis, Ashley Griggs, Katerina K. Adamama- Moraitou, Margaret Musser, Nectarios Soubasis, Dimitra Pardali, Thodoris S. Christoforidis,
  3. Last updated: October 7, 2024 Page 8 of 14. (ePoster)
  4. Mathios E. Mylonakis, Albert E. Jergens. American College of Veterinary Internal Medicine Annual Conference, Minneapolis, MN. June 2024.Post-FDA approval analysis of Stelfonta® (tigilanol tiglate) use by veterinary oncologists for canine mast cell tumors, Margaret Musser, Erin Roof, Pamela Jones (presenter), Chad Johannes, ESVONC, Alicante, Spain. May 2023. (Oral)
  5. Expression of Prostaglandin EP4 Receptor mRNA in Feline Oral Squamous Cell Carcinoma. Raquel Doke, Austin Viall, Rachel Phillips, Olufemi Fasina, Chad Johannes (presenter), Margaret Musser. Veterinary Cancer Society Annual Conference, Norfolk, VA. October 2022. (Poster)
  6. Post-FDA approval analysis of Stelfonta® (tigilanol tiglate) use by veterinary oncologists for canine mast cell tumors. Margaret Musser, Erin Roof, Pamela Jones, Chad Johannes (Presenter). Veterinary Cancer Society Annual Conference, Norfolk, VA. October 2022 (Oral).
  7. Cytomorphologic changes in blood leukocytes and erythrocytes in dogs receiving CHOP treatment for multicentric lymphoma. Joseph DiBenedetto, Laura VanVertloo, Margaret Musser, Chad Johannes, Ariel Nenninger, Jeremy Servantes, Shannon Hostetter, Austin Vial. American College of Veterinary Internal Medicine Annual Conference. June 2022. (Poster)
  8. Evaluation of accidental anthracycline overdoses in 16 dogs. Haylie C. Lawson (Presenter), Margaret Musser, Rebecca Regan, Antony S. Moore, Ann Hohenhaus, Brian Flexxner, Chad M. Johannes. Veterinary Cancer Society Annual Conference, Virtual (due to COVID-19 Pandemic). November 2021. (Oral)
  9. Retrospective evaluation of toceranib phosphate (Palladia®) in treatment of feline pancreatic carcinoma. Carlos Ortiz Rosario (Presenter), Margaret Musser, Jonathan Mochel, Erika Berger, Jessica Talbott, Chad M. Johannes. Veterinary Cancer Society Annual Conference, Virtual (due to COVID-19 Pandemic). November 2021. (Poster)
  10. Immunocidin non-specific immunotherapy with Concurrent Doxorubicin for Canine Splenic Hemangiosarcoma. Margaret Musser (Presenter), Giovanna M. Coto, Chelsea D. Tripp, Erin M. Romansik, Chad M. Johannes. Veterinary Cancer Society Annual Conference, Virtual (due to COVID-19 Pandemic). November 2021. (Poster)
  11. L-CHOP in Combination with Monoclonal Antibody (AT-005, Tactress) for Naive Canine Intermediate/High-Grade, Peripheral T-cell Lymphoma. Margaret Musser (Presenter), Craig Clifford, Philip Bergman, Laura Treml, Lydia Cook McAnulty, Elizabeth McNiel, Chad Johannes. American College of Veterinary Internal Medicine Annual Conference, Semi-live (due to COVID-19 Pandemic). June 2021. (Oral)
  12. mRNA Expression of the Prostaglandin Receptor EP4 in Canine Lymphoma. Margaret Musser (Presenter), Austin Viall, Rachel Phillips, Olufemi Fasina, Chad Johannes. American College of Veterinary Internal Medicine Annual Conference, On Demand (due to COVID-19 Pandemic). June 2021. (Poster)
  13. Adverse event profile of the therapeutic canine osteosarcoma vaccine, live Listeria vector. Margaret Musser (Presenter), Erika Berger, Chelsea Tripp, Craig Clifford, Philip Bergman, Chad Johannes. Veterinary Cancer Society Annual Conference, Virtual. October 2020. (Oral).
  14. Retrospective analysis of prognostic factors and treatment options for canine aortic body chemodectomas, Giovanna Coto (Presenter), Margaret Musser, Melissa Tropf, Jessica Ward, Yeon-Jung Seo, Johnathan Mochel, Chad Johannes. Veterinary Cancer Society Annual Conference, Houston, TX. October 2019. (Oral)
  15. In vitro and in vivo evaluation of high-dose ascorbate in dogs. Margaret Musser (Presenter), Alyssa Mahaffey, Melissa Fath, Garry Buettner, Brett Wagner, Jonathan Mochel, Chad Johannes. American College of Veterinary Internal Medicine Annual Conference. Phoenix, AZ. June 2019. (Oral)
  16. In vitro and in vivo evaluation of high-dose ascorbate in dogs. Margaret Musser, Alyssa Mahaffey, Melissa Fath, Garry Buettner, Brett Wagner, Jonathan Mochel, Chad Johannes (Presenter). Poster Presentation. European Society of Veterinary Oncology Annual Congress. Frankfurt, Germany. May 2019. (Oral)
  17. Expression of Prostaglandin EP4 Receptor in Multiple Canine Malignancies. Margaret Musser (Presenter), Austin Viall, Rachel Phillips, Jesse Hostetter, Chad Johannes. VCS 2018 Annual Conference. Louisville, KY. October 2018. (Oral)
  18. Evaluation of the potency and accuracy of compounded toceranib phosphate formulations. Sarah Marnin, Darren Berger (Presenter), Austin Viall, Dwayne Schrunk, Margaret Musser, Chad Johannes. VCS 2018 Annual Conference. Louisville, KY. October 2018. (Oral)
  19. Expression of Prostaglandin EP4 Receptor in Canine Osteosarcoma. Margaret Musser (Presenter), Austin Viall, Rachel Phillips, Jesse Hostetter, Chad Johannes (Presenter). European College of Veterinary Internal Medicine - Companion Animals Annual Congress. Rotterdam, The Netherlands. September 2018. (Poster)
  20. Retrospective evaluation of Palladia® use in the treatment of inoperable, metastatic, or recurrent canine pheochromocytomas. Margaret Musser (Presenter), Kathryn Taikowski, Chad Johannes, Philip Bergman. Poster Presentation. American College of Veterinary Internal Medicine Annual Conference. Seattle, WA. June 2018. (Poster)
  21. Intratumoral expression of serotonergic system genes htr1b, htr2a, htr2b, tph1, and slc6a4 in canine osteosarcoma. Austin Viall (Presenter), Shay Bracha, Jesse Hostetter, Chad Johannes, Margaret Musser, Rachel Phillips. Poster Presentation. American College of Veterinary Internal Medicine Annual Conference. Seattle, WA. June 2018. (Poster) 

Conference Presentations

  1. Comparative oncology and clinical trials update. Margaret Musser (Presenter). University of Iowa Sarcoma Symposium. Iowa City, IA. August 2023.
  2. Palliative Radiation Therapy for Canine Osteosarcoma. Margaret Musser (Presenter), Chad Johannes, Nicholas Rancilio, Keiko Murakami, Jessica Goetz, Ben- jamin Miller. University of Iowa Sarcoma Symposium, Virtual. Iowa City, IA. August 2022.
  3. The Science Behind High-Dose Intravenous Vitamin C in Cancer. Margaret Musser (Presenter). American College of Veterinary Internal Medicine Annual Confer- ence, On Demand (due to COVID-19 Pandemic). June 2021.
  4. Canine Osteosarcoma: What Clients Want to Know About New Treatment Options. Margaret Musser (Presenter) and Michael Nolan (Presneter). Veterinary Meeting and Expo, Virtual (due to the COVID-19 Pandemic). June 2021.
  5. Beyond COX2: The Role of EP4 Receptor Antagonists in Cancer. Margaret Musser (Presenter). American College of Veterinary Internal Medicine Annual Conference, On Demand (due to COVID-19 Pandemic). July 2020.
  6. Evaluation of Pharmacological Ascorbate in Dogs. Margaret Musser (Presenter), Alyssa Mahaffey, Melissa Fath, Garry Buettner, Brett Wagner, Jonathan Mochel, Chad Johannes. University of Iowa Sarcoma Symposium. Iowa City, IA. February 2020.
  7. Managing Cancer Pain. Margaret Musser. American College of Veterinary Internal Medicine Annual Conference. Phoenix, AZ. June 2019.
  8. Understanding Chemotherapy Administration, Reconstitution, and Storage. Margaret Musser (Presenter). American College of Veterinary Internal Medicine Annual Conference. Seattle, WA. June 2018.
  9. Evaluating High-Dose Intravenous Vitamin C Pharmacokinetics in Healthy Beagle Dogs. Margaret Musser (Presenter), Chad Johannes. University of Iowa Sarcoma Symposium. Iowa City, IA. February 2018.
  10. Chemotherapy: Logistics and Legality in Practice. Margaret Musser (Presenter). Iowa Veterinary Medicine Association Annual Meeting. Altoona, IA. February 2018.
  11. Tanovea: A New Treatment Option for Lymphoma. Margaret Musser (Presenter). Iowa Veterinary Medicine Association Annual Meeting. Altoona, IA. February 2018.
  12. Feline Oncology: What’s New. Margaret Musser (Presenter). Iowa Veterinary Medicine Association Annual Meeting. Altoona, IA. February 2018.
  13. Prostaglandin EP4 Receptor Expression in Canine Cancers. Margaret Musser (Presenter). Iowa State College of Veterinary Medicine Faculty Research Symposium. Ames, IA. January 2018.

Current Research Funding

  1. Veterinary Cancer Society Resident Grant, mRNA Expression of the Prostaglandin EP4 Receptor in Feline Oral Squamous Cell Carcinoma, Raquel N. Doke (PI), Margaret L. Musser (PI), Austin K. Viall, Rachel L. Philiips, $8,259.00 (2021)
  2. Iowa State University Veterinary Clinical Sciences Research Incentive Grant, Investigation of metabolomic biomarkers within prostatic fluid for the early identification of intact male dogs affected by benign prostatic hyperplasia, Joseph DiBenedetto (Co-PI), Theresa Beachler (Co-PI), Jean-Sebastien Palerme (Co-PI), Margaret Musser (Co-I), $5,000 (2021)
  3. Boehringer Ingelheim Animal Health USA INC. Animal Product Trial - BIAH anti-lymphoma IVP pilot clinical trial in dogs, Margaret L. Musser (PI), $139,860. (2020)
  4. American Holistic Veterinary Medical Association, Pilot study of high-dose ascorbate combined with carboplatin for canine osteosarcoma, Margaret L. Musser (PI), Chad M. Johannes, $22,172. (2020)
  5. Margaret B. Barry Foundation Grant, Using Canine Urothelial Cancer Organoids to Predict Treatment Responses for Human Bladder Cancer, Karin Allenspach, Jonathan Mochel, Albert Jergens, Chad Johannes, Margaret Musser, Jean-Sebastien Palerme, Megan Mickelson, Robert Jernigan, and Anne Bronikowski, $120,000. (2020)
  6. University of Iowa Sarcoma Multidisciplinary Oncology Group Funding Opportunity, A Study to Explore the Effect of External Beam Radiation on the Strength and Histology of Long Bones in a Canine Model, Benjamin Miller, Jessica Goetz, Bryan Allen, Mitchell Coleman, Marc Brouillette, Joshua Johnson, Doug Fredericks, Chad Johannes, Margaret Musser, Megan Mickelson, $50,000. (2020)