Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disease that affects young boys and rapidly renders their muscles dysfunctional. By studying this disease in a porcine model, we will be able to develop relevant treatments and assist those affected.
Heat stress negatively affects animal production and welfare. In the U.S. swine industry is approaching a $1 billion loss annually due to heat stress related disease and death. One reason for this economic loss is reduced muscle mass and increased adipose tissues resulting in decreased meat value. Gaining this mechanistic understanding of heat stress is necessary for the development of therapies to protect human patients from injury as well as maintain efficient meat production in an agricultural setting.