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c57 vs mdx

Disease and Muscle Dysfunction Lab

Dr. Joshua Selsby

DMD Lab

Dr. Joshua Selsby is a Professor in the Department of Animal Science at Iowa State University with courtesy appointments in Kinesiology and Biomedical Science. In addition to being a member of the graduate faculty in these departments, Dr. Selsby is a member of several interdepartmental graduate programs including Genetics and Genomics (IGG), Molecular, Cellular, and Developmental Biology (MCDB), and Nutrition. Members of the Disease and Muscle Dysfunction Lab are interested in mechanisms of muscle injury and the development of countermeasures and therapeutics to attenuate or reverse muscle injury. These efforts have been funded by NIH, USDA, and generous contributions by numerous research and advocacy foundations related to Duchenne muscular dystrophy.

Duchenne Muscular Dystrophy

Our work with Duchenne muscular dystrophy is focused on the role of dysfunctional autophagy in disease progression. We are also beginning to ask question about the role of obesity and insulin resistance in disease progression.

Heat Stress

We areĀ interested in how heat stress negatively impacts skeletal muscle physiology and growth.