Title: Protein Sequence Matching (R01)
Role: PI
Agency: NIGMS-NIH
Duration: February 1, 2018-January 31, 2023
Title: Novel Use of Genome Information to Understand Mutations (R01)
Role: PI
Agency: HGRI-NIH
Duration: September 13, 2021 - June 30, 2026
Sponsor: National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
Award amount: $480,608; five-year project, estimated total award of $2,343,048
The proliferation of low-cost genome sequencing is creating a wealth of data that this proposal, spearheaded by Curtiss Distinguished Professor of Biochemistry, Biophysics and Molecular Biology, intends to put to good use to gain a better understanding of disease mutations. The purpose of this NHGRI-funded project is to apply basic scientific advances in our understanding of protein structures, sequences, dynamics and binding to develop prediction software and databases that can aid directly in clinical disease interpretation. The ability to accomplish this is strongly supported by preliminary results demonstrating that mutants destructive of function, and their mechanisms of action, can be more reliably identified than is currently being done. Jernigan and his team will employ new, highly innovative and unique multi-faceted approaches that will produce translatable methods for screening neutral and disease mutants, while also making more reliable identifications of function. These approaches will also predict the effect of mutations that have not been previously reported. Overall, the project will meet the challenge of producing a gold standard against which to judge the phenotypic disease consequences of genetic variation.
Relevant grand challenge themes:
- Enabling healthy lives (plants, animals, people, communities)
- Advancing data-driven discovery
Title: Statistical Methods for Higher Order Dependences to Understand Protein Functions (R01)
Role: Co-PI (PI: Wen Zhao)
Agency: NIH-NIGMS
Duration: September 1,2021 – August 31, 2024
Title: Novel Systems Approach for Rational Engineering of Robust Microbial Pathways
Role: Co-PI (PI: Laura Jarboe)
Agency: DOE
Duration: September 1, 2021 - August 31, 2024
Title: Defining the architecture of the Pyk2 activation complex
Role: Co-PI (PI: Eric Underbakke)
Agency: NSF-MCB
Duration: September 15, 2017 – September 14, 2022
Title: Defining the structural organization of the polysaccharide-synthesizing multiprotein complexes localized in Golgi
Role: Co-PI (PI: Olga Zabotina)
Agency:NSF-MCB
Duration: 2019-2022