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Highlighted SCID Works (newest to oldest)

Singer, A.J. et al. Survival of Human Cadaver Skin on SCID Pigs: Proof of ConceptWound Repair Regen. 2020. 27 (4): 426-430

Human skin survives on SCID pigs.



Boettcher A.N. and Li, Y et al. Novel Engraftment and T cell Differentiation of Human Hematopoietic Cells in ART-/- IL2RG-/Y SCID Pigs. Front. Immunol. 2020. 11: 100

Engraftment of human immune cells in SCID pigs.



Annamalai T. et al. Infectivity of GII.4 human norovirus does not differ between T-B-NK+ severe combine immunodeficiency (SCID) and non-SCID gnotobiotic pigs, implicating the role of NK cells in mediation of human norovirus infection. Virus Res. 2019. 267: 21-25

Human norovirus in SCID pigs.



Boettcher A.N. et al. Human Ovarian Cancer Tumor Formation in Severe Combined Immunodeficient Pigs. Front Oncol. 2019. 9: 9

Human ovarian tumors in SCID pigs.



Boettcher, A.N. et al. Porcine SIRPA Binds to Human CD47 to Inhibit Phagocytosis: Implications for Human Hematopoietic Stem Cell Transplantation into Severe Combined Immunodeficient PigsXenotransplantation. 2019. 26 (2): e12466

Porcine Sirpa binds to human CD47.



Powell, E.J. et al. Creating Effective Biocontainment Facilities and Maintenance Protocols for Raising Specific Pathogen-free, Severe Combined Immunodeficient (SCID) Pigs. Lab Anim. 2018. 52 (4): 402-412

Biocontainment Facilities.



Powell, E.J. et al. NK cells are Intrinsically Functional in Pigs with Severe Combined Immunodeficiency (SCID) caused by Spontaneous Mutations in the Artemis Gene. Vet Immunol Immunopathol. 2016. 175: 1-6

NK cells in SCID pigs.



Waide, E.H. et al. Not All SCID Pigs Are Created Equally: Two Independent Mutations in the Artemis Gene Cause SCID in Pigs. J Immunol. 2015. 195 (7): 3171-3179

Artemis SCID pigs.



SCID Pig Review Articles

Boettcher A.N. et al. Development of Severe Combined Immunodeficient (SCID) Pig Models for Translational Cancer Modeling: Future Insights on How Humanized SCID Pigs Can Improve Preclinical Cancer Research. Front Oncol. 2018. 8: 559

Powell E.J. et al. SCID Pigs: an Emerging Large Animal NK Model. J Rare Dis Res Treat. 2017. 2(3): 1-6




Highlighted FAANG Research, Review Articles, and White Papers

Herrera-Uribe, J. et al. Changes in H3K27ac at Gene Regulatory Regions in Porcine Alveolar Macrophages Following LPS or PolyIC Exposure. Front. Genetics. 2020. 11: 817

Alveolar Macrophage VA


Herrera-Uribe, J and Wiarda, JE et al. Reference transcriptomes of porcine peripheral immune cells created through bulk and 1single-cell RNA sequencing. Submitted to BioRxiv April 4, 2021.

Single cell VA


Clark E. et al. From FAANG to Fork: Application of Highly Annotated Genomes to Improve Farmed Animal Production. Genome Biol. 2020. 21: 285

Giuffra E. et al. Functional Annotation of ANimal Genomes (FAANG): current achievements and roadmap. Annual Review of Animal Biosciences. 7: 65-88.

Tuggle CK. et al. GO-FAANG: a Gathering On Functional Annotation of ANimal Genomes. Animal Genetics. 47: 528-533.

The FAANG Consortium (49 authors, CK Tuggle as co-corresponding author). Coordinated international action to accelerate genome to phenome with FAANG, the Functional Annotation of Animal Genomes project. Genome Biology. 2015. 16:57