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Recent Publications (2016 - current)

Mao, S., Fonder, C., Rubby, F., Yang, R., Phillips, G., Sakaguchi, D.S., Que, L. (2022) A microchip for studying the effects of dopamine and its precursor on neurospheroids. 2022 IEEE 35th International Conference on Micro Electro Mechanical Systems Conference (MEMS), 2022, pp. 305-308, doi: 10.1109/MEMS51670.2022.9699585.

Yang, R.+, Fonder, C.,+ Sylvester, T., Peng, S., Jiles, D., Sakaguchi, D.S.,* and Que, L. * (2021) A microfluidic chip for growth and characterization of adult rat hippocampal progenitor cell neurospheroids. IEEE/ASME Journal of Microelectromechanical Systems10.1109/JMEMS.2021.3134632 (+, contributed equally to the manuscript; *, co-senior authors).

Mammadova, N., Moore, J., Sakaguchi, D.S., Greenlee, J.J., and West Greenlee, M.H Experimental study using multiple strains of prion disease in cattle reveals an inverse relationship between incubation time and misfolded prion accumulation, neuroinflammation  and autophagy. American J. Pathology

Patel, B.B., McNamara, M.C., Pesquera-Colom, L.S., Kozik, E.M., Okuzonu, J., Hashemi, N.N. and Sakaguchi, D.S. 2020. Recovery of encapsulated adult neural progenitor cells from microfluidic-spun hydrogel fibers enhances proliferation and neuronal differentiation. ACS Omega. 5, 14. 7910-7918.

Sakaguchi, D.S. (2019) Genetic Manipulation and Selection of Mouse Mesenchymal Stem Cells for Delivery of Therapeutic Factors in vivo. In: Bertoncello I. (eds) Mouse Cell Culture. Methods in Molecular Biology, vol 1940. Humana Press, New York, NY.

Sandquist EJ, Sakaguchi DS (2019) Adult neural stem cell plasticity. Neural Regen Res 14(2):256-257. doi:10.4103/1673-5374.244785.

Patel, B.B., Sharma, A.D., Mammadova, N., Sandquist, E., Uz, M., Mallapragada, S.K., and Sakaguchi, D.S. (2019) Nanoengineered biomaterials for retinal repair. pp 215-264. In “Nanoengineered Biomaterials for Regenerative Medicine”, D. Kaplan, J. Rajadas, and M. Mozafari (eds.). Elsevier. (

Yang, R., E. Kozik, D. Jiles, D. Sakaguchi, and L. Que, Studies of neurospheres cultured using adult hippocampal progenitor cells under off-chip magnetic stimulation, in Proc. Transducers' 2019. 2019: Berlin, Germany. p. 756-759.

Patel, B.B., Clark, K.L., Kozik, E.M., Dash, L., Kuhlman, J.L. and Sakaguchi, D.S. (2019) Isolation and culture of primary embryonic zebrafish neural tissue. J. Neurosci. Methods. 328: 108419.

Sharifi, F., Patel, B.B., McNamara, M.C., Meis, P.J., Roghair, M.N., Lu, M., Montazami, R., Sakaguchi, D.S., Hashemi, N.N. (2019) Photo-cross-linked poly (ethylene glycol) diacrylate hydrogels: Sphereical microparticles to bow tie-shaped microfibers. ACS Appl. Mater. Interfaces. 11. 20. 18797-18807.

Uz, M., Hondred J. A.; Donta M.; Juhyung J.; Kozik E.; Sandquist E. J.; Sakaguchi D. S.; Claussen J. C.; and Mallapragada S., Determination of Electrical Stimuli Parameters to Transdifferentiate Genetically Engineered Mesenchymal Stem Cells into Neuronal or Glial Lineages. Regenerative Engineering and Translational Medicine, 2019, 1-11. (In Honor of Robert Langer's 70th Birthday) (                               

Uz, M., Donta, M.; Mededovic, M.; Sakaguchi, D. S.; Mallapragada, S. K., Development of Gelatin and Graphene-Based Nerve Regeneration Conduits Using 3D Printing Strategies for Electrical Transdifferentiation of Mesenchymal Stem Cells. ACS Industrial & Engineering Chemistry Research 2019, 58, 18, 7421-7427. (

Patel, B.B, Sharifi, F., Stroud, D.P., Montazami, R., Hashemi, N.N. and Sakaguchi, D.S. (2019) 3-D Microfibrous Scaffolding Selectively Promotes Proliferation and Glial Differentiation of Adult Neural Stem Cells: A Platform to Tune the Cellular Behavior in Neural Tissue Engineering. Macromolecular Bioscience. Selected for cover illustration

De la Rosa M.B., Kozik E.M., Sakaguchi D.S. (2018) Adult Stem Cell-Based Strategies for Peripheral Nerve Regeneration. In: Advances in Experimental Medicine and Biology. Springer, New York, NY. DOI

Uz, M., Das, S.R., Ding, S., *Sakaguchi, D.S., *Claussen, J.C. and *Mallapragada, S.K. 2018. Advances in Controlling Differentiation of Adult Stem Cells for Peripheral Nerve Regeneration. Advanced Functional Materials. DOI 10.1002/adhm.201701046. *co-corresponding authors.

Mammadova, N., Kokemuller, R.D., Summers, C.M., He, Q., Ding, S., Baron, T., Yu, C., Valentine, R.J., Sakaguchi, D.S., Kanthasamy, A.G., Greenlee, J.J., West Greenlee, M.H. Accelerated accumulation of retinal α-synuclein (pSer129) and tau, neuroinflammation and autophagic dysregulation in a seeded mouse model of Parkinson’s disease. Neurobiol. Dis. 2018 Sep 12. pii: S0969-9961(18)30204-3. doi: 10.1016/j.nbd.2018.09.013.

Sandquist, E.J., Essner, J.J., and Sakaguchi, D.S. (2018) Xenotransplantation of adult hippocampal neural progenitors into the developing zebrafish for assessment of stem cell plasticity. PLOS ONE.

D.S. Sakaguchi. 2017. Regenerative and Repair Strategies for the Central Nervous System. In “Neuroimmune Pharmacology, Second Edition”. T. Ikezu and H. Gendelman (eds.). Springer.

Bierlein del la Rosa, M., Sharma, A.D., Mallapragada, S.K., and Sakaguchi, D.S. (2017) Transdifferentiation of BDNF-hypersecreting MSCs significantly enhances BDNF secretion and Schwann cell marker proteins. J Biosci Bioeng. 124(5), 572-582. doi: 10.1016/j.jbiosc.2017.05.014. PMID: 28694020

Sharma, A.D., Weiderin, J., Uz, M. Ciborowski, P., Mallapragada, S.K., Gendelman, H. E., and Sakaguchi, D.S. (2017) Proteomic analysis of mesenchymal to Schwann cell transdifferentiation. J. Proteomics. 195: 93-101.  doi: 10.1016/j.prot.2017.06.011. PMID: 28629798 (

Mammadova, N., Ghaisas, S., Zenitsky, G., Sakaguchi, D.S., Kanthasamy, A.G., Greenlee, J.J. and West Greenlee, M.H. 2017. Lasting retinal injury in a mouse model of blast-induced trauma. Am J Path. 187: 1459-1472. PMID: 28606756. DOI: 10.1016/j.ajpath.2017.03.005

Uz, M., Büyüköz, M., Sharma, A.D., Sakaguchi, D.S., Altinkaya, S.A., Mallapragada, S.K. Gelatin-based 3D conduits for transdifferentiation of mesenchymal stem cells into Schwann cell-like phenotypes. Acta Biomater. 2017 53:293-306. doi: 10.1016/j.actbio.2017.02.018. PMID: 28213098 (

Das, S.R.,# Uz, M.,# Ding, S., Lentner, M.T., Hondred, J.A., Cargill, A.A., Sakaguchi, D.S., Mallapragada, S.K., Claussen, J.C. Electrical Differentiation of Mesenchymal Stem Cells into Schwann Cell-Like Phenotypes using Inkjet Printed Graphene Circuits. Adv Healthc Mater. 2017, 6(7) doi: 10.1002/adhm.201601087. ( (#Authors with equal contributions). Selected as cover art.

E.J. Sandquist, M. Uz, A.D. Sharma, B.B. Patel, S.K. Mallapragada and D.S. Sakaguchi (2016). Stem cells, bioengineering and 3-D scaffolds for nervous system repair and regeneration. In “Neural Engineering: from Advanced Biomaterials to 3D Fabrication Techniques”, L.G. Zhang and D. Kaplan (eds.). Springer

Cover-Macromolecular Bioscience




Biotech 2014


BioTech 2013


Stem Cell Biology


Dev Biol


Bio Tech 2012






Dev Brain Res 99


Dev Brain Res 96


Bio Tech 2008


Bio Tech 2007


Bio Tech 2006


Bio Tech 2000