Yang Yang

Within the last two decades, three highly pathogenic human coronaviruses have emerged and caused global economic and public health crises. The Yang Lab strives to elucidate the structures and dynamics of the coronavirus replication-transcription machinery and how they are modulated by various viral and host factors. Through the integration of structural, biochemical, cell biological, and computational approaches, we are revealing the mechanisms and regulation of SARS-CoV-2 RNA synthesis and developing antivirals to battle COVID-19 and potential outbreaks of deadly coronaviruses in the future.