In this project, we are evaluating how the genetics and genomics of the host impact its response to diseases (e.g. PRRS) and other stressors (e.g. heat-stress), with or without interacting with other sources of variation (e.g. microbiome). We are interesting in investigating how the host response to these diseases and pathogens, using high-throughput phenotype and genomic technologies, and machine learning and other complex statistical algorithms, while addressing the critical needs of the industry.
Published work* led by the Serão Genomic Lab related to this Project (in chronological order):
*Only publications with final references are shown
Host Genetic Variation to Diseases in Pigs
39) Sanglard LP*, PigGen Canada, BE Mote, P Willson, JCS Harding, GS Plastow, JCM Dekkers, NVL Serão^ (2020) Genomic analysis of IgG antibody response to common pathogens in commercial sows in health-challenged herds. Frontiers in Genetics, 11:593804. doi: https://doi.org/10.3389/fgene.2020.593804
38) Sanglard LP*, RL Fernando, KA Gray, DCL Linhares, JCM Dekkers, MC Niederwerder, NVL Serão^ (2020) Genetic analysis of antibody response to Porcine Reproductive and Respiratory Syndrome vaccination as an indicator trait for reproductive performance in commercial sows. Frontiers in Genetics, 11:1011. doi: https://doi.org/10.3389/fgene.2020.01011
37) Sanglard LP*, S Schmitz-Esser, KA Gray, DCL Linhares, CJ Yeoman, JCM Dekkers, MC Niederwerder, NVL Serão^ (2020) Vaginal microbiota diverges in sows with low and high reproductive performance after porcine reproductive and respiratory syndrome vaccination. Scientific Reports, 10:3046. https://doi.org/10.1038/s41598-020-59955-8
36) Sanglard LP*, S Schmitz-Esser, KA Gray, DCL Linhares, CJ Yeoman, JCM Dekkers, MC Niederwerder, NVL Serão^ (2020) Investigating the relationship between vaginal microbiome and host-genetics and their impact on immune response and farrowing traits in commercial gilts. Journal of Animal Breeding and Genetics, 137(1):84-102. doi: https://doi.org/10.1111/jbg.12456
35) Sanglard LP*, RL Fernando, KA Gray, DCL Linhares, JCM Dekkers, MC Niederwerder, NVL Serão^ (2020) Genomic relationship between antibody response to porcine reproductive and respiratory syndrome virus vaccination and reproductive performance in commercial sows. In: Journal of Animal Sciences, 98(Issue Suppl. 4):20-21. ASAS-CSAS Annual Meeting & Trade Show, Madison, WI, USA, 2020. doi: https://doi.org/10.1093/jas/skaa278.038
34) Neveau MN*, LP Sanglard *, JCM Dekkers, E Little, S Dee, D Hanson, PK Mathur, E Knol, J Eggert, JR Dunkelberger, NVL Serão^ (2020) Host genetics of antibody reponse to PRRS vaccination and infection in growing pigs. In: Journal of Animal Sciences, 98(Issue Suppl. 4):19. ASAS-CSAS Annual Meeting & Trade Show, Madison, WI, USA, 2020. doi: https://doi.org/10.1093/jas/skaa278.036
33) Braccini Neto J*, LP Sanglard *, S Schmitz-Esser, KA Gray, DCL Linhares, CJ Yeoman, JCM Dekkers, MC Niederwerder, NVL Serão^ (2020) Vaginal microbiome composition is associated with sow longevity. In: Journal of Animal Sciences, 98(Issue Suppl. 4):23-24. ASAS-CSAS Annual Meeting & Trade Show, Madison, WI, USA, 2020. doi: https://doi.org/10.1093/jas/skaa278.043
32) Hickmann FMW*, J Braccini Neto, LM Kramer, KA Gray, JCM Dekkers, LP Sanglard*, NVL Serão^ (2020) Genomic basis of reproductive performance in PRRSV-infected sows. In: Journal of Animal Sciences, 98(Issue Suppl. 3):162–163. ASAS Midwest Section Meeting, Omaha, NE, USA, 2020. doi: https://doi.org/10.1093/jas/skaa054.287
31) Hickmann FMW*, J Braccini Neto, LM Kramer, KA Gray, Y Huang, JCM Dekkers, LP Sanglard*, NVL Serão^ (2020) Accuracies of genomic prediction for reproductive traits in PRRSV-infected sows. In: Journal of Animal Sciences, 98(Issue Suppl. 3):163. ASAS Midwest Section Meeting, Omaha, NE, USA, 2020. doi: https://doi.org/10.1093/jas/skaa054.288
30) Sanglard LP*, RL Fernando, KA Gray, DCL Linhares, JCM Dekkers, MC Niederwerder, NVL Serão^ (2020) Genomic basis of antibody response to Porcine Reproductive and Respiratory Syndrome virus vaccination. In: Journal of Animal Sciences, 98(Issue Suppl. 3):28. ASAS Midwest Section Meeting, Omaha, NE, USA, 2020. doi: https://doi.org/10.1093/jas/skaa054.050
29) Scanlan CL*, AM Putz, KA Gray, NVL Serão^ (2019) Genetic evaluation of reproductive performance in sows during PRRS and PED outbreaks. Journal of Animal Science and Biotechnology, 10:22. doi: https://doi.org/10.1186/s40104-019-0330-0
28) Serão NVL^, LP Sanglard* (2019) Predicting reproductive performance of commercial sows using genetic markers, acclimation procedures, and new traits. In: Allen D. Leman Swine Conference Proceedings. 2019 Allen D. Leman Swine Conference, St. Paul, MN, USA. (Invited Oral Presentation)
27) Hickmann FMW*, J Braccini Neto, LM Kramer, LP Sanglard*, KA Gray, JCM Dekkers, NVL Serão^ (2019) Accuracy of genomic prediction for total antibody response in purebred sows during a PRRS outbreak. In: 2019 NA PRRS Symposium Proceedings, 28. North American PRRS Symposium, Chicago, IL, USA.
26) Hickmann FMW*, J Braccini Neto, LM Kramer, LP Sanglard*, KA Gray, JCM Dekkers, NVL Serão^ (2019) Host-genomic scan for total antibody response during a PRRSV outbreak in purebred sows. In: 2019 NA PRRS Symposium Proceedings, 27. North American PRRS Symposium, Chicago, IL, USA.
225) Sanglard LP*, S Schmitz-Esser, KA Gray, DCL Linhares, CJ Yeoman, JCM Dekkers, MC Niederwerder, NVL Serão^ (2019) Association between vaginal microbiome and antibody response to PRRS vaccination in commercial gilts. In: 2019 NA PRRS Symposium Proceedings, 29. North American PRRS Symposium, Chicago, IL, USA.
24) Sanglard LP*, S Schmitz-Esser, KA Gray, DCL Linhares, CJ Yeoman, JCM Dekkers, MC Niederwerder, NVL Serão^ (2019) The vaginal microbiome composition of PRRS-vaccinated gilts differs between animals with high and low farrowing performance. In: 2019 NA PRRS Symposium Proceedings, 30. North American PRRS Symposium, Chicago, IL, USA.
23) Sanglard LP*, S Schmitz-Esser, KA Gray, DCL Linhares, CJ Yeoman, JCM Dekkers, MC Niederwerder, NVL Serão^ (2019) Relationship between host-genetics and the vaginal microbiome in commercial. In: Journal of Animal Sciences, 97(Suppl. 3):43–44. ASAS-CSAS Annual Meeting & Trade Show, Austin, TX, USA, 2019. doi: https://doi.org/10.1093/jas/skz258.086
22) Scanlan CL*, PigGen Canada, BE Mote, P Willson, JCS Harding, SC Bishop, GS Plastow, JCM Dekkers, NVL Serão^ (2019) Genomic prediction for reproductive traits in commercial sows in health challenged herds. In: Journal of Animal Sciences, 97(Suppl. 2):166. ASAS Midwest Section Meeting. doi: https://doi.org/10.1093/jas/skz122.293
21) Sanglard LP*, PigGen Canada, BE Mote, P Willson, JCS Harding, SC Bishop, GS Plastow, JCM Dekkers, NVL Serão^ (2019) Identification of QTL associated with common infectious diseases in commercial sows in health challenged herds. In: Journal of Animal Sciences, 97(Suppl. 2):33-34. ASAS Midwest Section Meeting. doi: https://doi.org/10.1093/jas/skz122.062
20) Sanglard LP*, PigGen Canada, BE Mote, P Willson, JCS Harding, SC Bishop, GS Plastow, JCM Dekkers, NVL Serão^ (2019) Accuracy of genomic prediction of common infectious diseases in commercial sows in health challenged herds. In: Journal of Animal Sciences, 97(Suppl. 2):168-169. ASAS Midwest Section Meeting. doi: https://doi.org/10.1093/jas/skz122.298
19) Ferring CL*, PigGen Canada, BE Mote, P Willson, JCS Harding, SC Bishop, GS. Plastow, JCM Dekkers, NVL Serão^ (2018) Genomic analysis of reproductive traits in commercial sows in health challenged herds. In: Proceedings of the 11th World Congress on Genetics Applied to Livestock Production. 11th World Congress on Genetics Applied to Livestock Production, Auckland, New Zealand. http://www.wcgalp.org/system/files/proceedings/2018/genomic-analysis-reproductive-traits-health-challenged-commercial-sow-herds.pdf
18) Hickmann* FMW, J Braccini Neto, DCL Linhares, KA Gray, JCM Dekkers, MC Niederwerder, NVL Serão^ (2018) Genomic analysis of total antibody response to Porcine Reproductive and Respiratory Syndrome (PRRS) Modified Live Virus (MLV) vaccination in commercial replacement gilts. In: 2018 NA PRRS Symposium Proceedings, 45. North American PRRS Symposium, Chicago, IL, USA. https://www.vet.k-state.edu/na-prrs/docs/2018-proceedings.pdf(Selected Oral Presentation)
17) Ferring CL*, BE Mote, P. Willson, JCS Harding, GS Plastow, JCM Dekkers, PigGen Canada, NVL Serão^ (2017) Genetic Analysis of Reproductive Traits in Commercial Sows in Health Challenged Herds. In: 2017 Joint NSIF and NA PRRS Symposium Proceedings, 65. Joint Meeting of the National Swine Improvement Federation and North American PRRS Symposium, Chicago, IL, USA. https://www.vet.k-state.edu/na-prrs/docs/2017-proceedings.pdf
16) Ferring CL*, KA Gray, NVL Serão^ (2017) Reaction norms for reproductive performance during PRRS and PED outbreaks. In: Journal of Animal Sciences, 95(Suppl. 5):16-17. ADSA®-ASAS Joint Midwest Meeting, Omaha, NL, USA, 2017. doi: https://doi.org/10.2527/asasmw.2017.035
15) Serão NVL, RA Kemp, BE Mote, JCS Harding, P Willson, SC Bishop, GS Plastow, JCM Dekkers (2016) Genetic improvement of sow and gilt reproductive performance via PRRS immunity. In: Advances in Pork Production, 27:145-54. 2016 Banff Pork Seminar, Banff, AB, Canada. https://www.banffpork.ca/documents/170308043700Nick%20Serao_Genetic%20Improvement%20of%20Sow%20&%20Gilt.pdf
14) Serão NVL, RA Kemp, BE Mote, JCS Harding, P Willson, SC Bishop, GS Plastow, JCM Dekkers (2016) Genetic and Genomic basis of antibody response to Porcine Reproductive and Respiratory Syndrome (PRRS) in gilts and sows. Genetics Selection Evolution, 48:51. doi: https://doi.org/10.1186/s12711-016-0230-0
13) Serão NVL, RA Kemp, BE Mote, JCS Harding, P Willson, SC Bishop, GS Plastow, JCM Dekkers (2016) Genetic variation for antibody response to a range of pathogens in commercial replacement gilts. In: 2016 NA PRRS Symposium Proceedings, 59. North American PRRS Symposium, Chicago, IL, USA. (Poster) https://www.vet.k-state.edu/na-prrs/docs/2016-proceedings.pdf
12) Berg K*, CL Ferring*, KA Gray, NVL Serão^ (2016) Effect of PEDV and PRRSV outbreaks on reproductive performance of commercial sows. In: 2016 NA PRRS Symposium Proceedings, 34. North American PRRS Symposium, Chicago, IL, USA. https://www.vet.k-state.edu/na-prrs/docs/2016-proceedings.pdf
11) Ferring CL*, KA Gray, NVL Serão^ (2016) Genetic evaluation of reproductive performance during PRRS/PED outbreaks. In: 2016 NA PRRS Symposium Proceedings, 46. North American PRRS Symposium, Chicago, IL, USA. https://www.vet.k-state.edu/na-prrs/docs/2016-proceedings.pdf
10) Serão NVL, RA Kemp, BE Mote, JCS Harding, P Willson, SC Bishop, GS Graham, JCM Dekkers (2015) Genomic relationship between number of mummified piglets during PRRS outbreak and antibody response. In: 2015 NA PRRS Symposium Proceedings, 74. North American PRRS Symposium, Chicago, IL, USA. (Poster) https://www.vet.k-state.edu/na-prrs/docs/2015-proceedings.pdf
9) Serão NVL, RA Kemp, BE Mote, JCS Harding, P Willson, SC Bishop, GS Plastow, JCM Dekkers (2015) Genomic prediction accuracy of Porcine Reproductive and Respiratory Syndrome (PRRS) antibody response in commercial gilts and sows. Journal of Animal Sciences, 93(E-Suppl. 3):846. ADSA®-ASAS Joint Annual Meeting, Orlando, FL, USA, 2015. (Oral Presentation)
8) Serão NVL, O Matika, RA Kemp, J Harding, SC Bishop, GS Plastow, JCM Dekkers (2014) Genetic analysis of reproductive traits and antibody response in a PRRS outbreak herd. Journal of Animal Science, 92:2905-21. doi: https://doi.org/10.2527/jas.2014-7821
7) Serão NVL, RA RA Kemp, BE Mote, JCS Harding, P Willson, SC Bishop, GS Plastow, JCM Dekkers (2014) Whole-genome scan and validation of regions previously associated with PRRS antibody response and growth rate under health challenge in commercial settings. In: Proceedings of the 10thWorld Congress on Genetics Applied to Livestock Production. 10th World Congress on Genetics Applied to Livestock Production, Vancouver, BC, Canada. http://www.wcgalp.org/system/files/proceedings/2014/whole-genome-scan-and-validation-regions-previously-associated-prrs-antibody-response-and-growth.pdf (Oral Presentation)
6) Serão NVL, RA Kemp, BE Mote, JCS Harding, P Willson, SC Bishop, GS Plastow, JCM Dekkers (2014) Antibody response during a Porcine Reproductive and Respiratory Syndrome (PRRS) outbreak can be predicted using high-density SNP genotypes. In: 2014 NA PRRS Symposium Proceedings, 81. North American PRRS Symposium, Chicago, IL, USA. (Poster)
5) Serão NVL, TE Burkey, G Gourley, TE Weber, M FitzSimmons, K Schwartz, C Sparks, J Odle, JCM Dekkers, NK Gabler (2014) Blood biomarkers for growth performance in gilts infected with Porcine Reproductive and Respiratory Syndrome (PRRS) virus. In: 2014 NA PRRS Symposium Proceedings, 82. North American PRRS Symposium, Chicago, IL, USA. (Poster)
4) Serão NVL, MC Niederwerder, MS Herrmann, MA Kerrigan, RRR Rowland, JK Lunney, JCM Dekkers (2014) Response to PRRSV and PCV2b is affected by vaccination and WUR genotype in nursery pigs. In: Journal of Animal Sciences, 92(E-Suppl. 2):i. ADSA®-ASAS Joint Annual Meeting, Kansas City, MO, USA, 2014. (Oral Presentation - Late Breaking Abstract)
3) Serão NVL, TE Burkey, G Gourley, TE Weber, M FitzSimmons, K Schwartz, C Sparks, J Odle, NK Gabler, JCM Dekkers (2014) Characterization of PRRS progression in growing gilts using metabolic, cytokine and complete blood count data. In: Journal of Animal Sciences, 92(E-Suppl. 2):72. ADSA®-ASAS Joint Midwest Meeting, Des Moines, IA, USA, 2014. (Oral Presentation)
2) Serão NVL, O Matika, RA Kemp, J Harding, SC Bishop, GS Plastow, JCM Dekkers (2013) Genetic analysis of reproductive traits and antibody response in a commercial sow herd before and after a PRRS outbreak. In: 2013 NA PRRS Symposium Proceedings, 66. North American PRRS Symposium, Chicago, IL, USA. (Poster)
1) Serão NVL, O Matika, RA Kemp, J Harding, SC Bishop, GS Plastow, JCM Dekkers (2013) GWAS for reproduction traits and antibody response in PRRS infected sows. In: Allen D. Leman Swine Conference Proceedings, 16:185. 2013 Allen D. Leman Swine Conference, St. Paul, MN, USA. (Poster)
Host Genetic Variation to Fescue Toxicosis in Beef Cattle
9) Galliou JM*, P Khanal*, K Mayberry, MH Poore, DH Poole, NVL Serão^ (2020) Evaluation of a new commercial genetic test for fescue toxicosis in pregnant Angus beef cattle. Translational Animal Science, 4(4):1-10, txaa181. doi: https://doi.org/10.1093/tas/txaa181
8) Koester LR, DH Poole, NVL Serão^, S Schmitz-Esser (2020) Beef cattle that respond differently to fescue toxicosis have distinct gastrointestinal tract microbiota. PLoS ONE, 15(7): e0229192. 10.1371/journal.pone.0229192
7) Khanal P*, LP Sanglard*, K Mayberry, J Sommer, MH Poore, DH Poole, NVL Serão^ (2019) Genes and functions associated with tolerance to fescue toxicosis in Angus cows. In: Journal of Animal Sciences, 97(Suppl. 2):167. ASAS Midwest Section Meeting. doi: https://doi.org/10.1093/jas/skz122.295
6) Khanal P*, LMP Sanglard*, JE Koltes, J Sommer, JE Koltes, NVL Serão^ (2018) Genetics of fescue toxicity in Angus cattle: Identification of differentially expressed genes in tolerant and susceptible Angus cows. In: Proceedings of the 11th World Congress on Genetics Applied to Livestock Production. 11thWorld Congress on Genetics Applied to Livestock Production, Auckland, New Zealand. http://www.wcgalp.org/system/files/proceedings/2018/genetics-fescue-toxicity-angus-cattle-identification-differentially-expressed-genes-tolerant-and.pdf
5) Koester LR, DH Poole, NVL Serão^, S Schmitz-Esser (2018) Effect of genetic response to endophyte-infected fescue on beef cattle gastrointestinal tract microbiota. In: Journal of Animal Sciences, 96(Suppl. S2):12-13. ADSA®-ASAS Joint Midwest Meeting, Omaha, NL, USA, 2018. doi: https://doi.org/10.1093/jas/sky073.021
4) Serão NVL^, JE Koltes, S Schmitz-Esser, DH Poole (2018) Investigating Host-Genetic Mechanisms Associated with Fescue- and Heat-Stress Tolerance in Cattle. Plant & Animal Genome XXII, San Diego, CA, USA, 2018. (Invited Oral Presentation) https://pag.confex.com/pag/xxvi/meetingapp.cgi/Paper/30314
3) Khanal P*, KJ Mayberry, MH Poore, DH Poole, NVL Serão^ (2017) Effect of genetic response to fescue toxicity on body weight, body temperature, hair coat, hair shed and body condition score in Angus cows. In: Journal of Animal Sciences, 95(Suppl. 1):18-19. ASAS Southern Section Meeting, Franklin, TN, USA, 2017. doi: https://doi.org/10.2527/ssasas2017.038
2) Galliou JM*, P Khanal*, KJ Mayberry, MH Poore, DH Poole, NVL Serão^ (2017) Evaluating the accuracy of a new commercial genetic test for response to fescue toxicosis in cattle. In: Journal of Animal Sciences, 95(Suppl. 1):55-56. ASAS Southern Section Meeting, Franklin, TN, USA, 2017. doi: https://doi.org/10.2527/ssasas2017.0113
1) Galliou JM*, P Khanal*, KJ Mayberry, MH Poore, DH Poole, NVL Serão^ (2016) Evaluating the accuracy of a new commercial genetic test for response to fescue toxicosis in cattle. State of North Carolina Undergraduate Research & Creativity Symposium, Durham, NC, USA, 2016.
Transcriptomic Response to Maternal Stressors
5) Carvalho EB*, LP Sanglard*, M Nascimento*, P Moriel, J Sommer, M Ashwell, MH Poore, MS Duarte, NVL Serão^ (2020) miRNAs explain variation in the muscle and blood transcriptomes of beef calves born from dams with or without energy restriction during late gestation. In: Journal of Animal Sciences, 98(Issue Suppl. 3):165. ASAS Midwest Section Meeting, Omaha, NE, USA, 2020. doi: https://doi.org/10.1093/jas/skaa054.292
4) Carvalho E*, LP Sanglard*, JM Meneses, DR Casagrande, Duarte MS, MP Gionbelli, NVL Serão^ (2020) Differentially expressed genes and their biological function in skeletal muscle of calves born from cows with or without protein supplementation during mid-gestation. In: Journal of Animal Sciences, 98(Issue Suppl. 3):165–166. ASAS Midwest Section Meeting, Omaha, NE, USA, 2020. doi: https://doi.org/10.1093/jas/skaa054.293
3) Sanglard LMP*, M Nascimento*, P Moriel, J Sommer, M Ashwell, MH Poore, MS Duarte, NVL Serão^ (2018) Impact of energy restriction during late gestation on the muscle and blood transcriptome of beef calves after preconditioning. BMC Genomics, 19:702. doi: https://doi.org/10.1186/s12864-018-5089-8
2) Sanglard LMP*, M Nascimento*, P Moriel, J Sommer, M Ashwell, MS Duarte, NVL Serão^ (2018) Effect of energy restriction during late gestation in the skeletal muscle and blood transcriptome of Angus calves after preconditioning. In: Proceedings of the 11th World Congress on Genetics Applied to Livestock Production. 11th World Congress on Genetics Applied to Livestock Production, Auckland, New Zealand. http://www.wcgalp.org/system/files/proceedings/2018/effect-energy-restriction-during-late-gestation-skeletal-muscle-and-blood-transcriptome-angus-calves.pdf
1) Sanglard LMP*, M Nascimento*, P Moriel, M Ashwell, MH Poore, MS Duarte, NVL Serão^ (2017) Effect of maternal nutrition and sex on skeletal muscle gene expression in Angus cattle during immune challenge. In: Journal of Animal Sciences, 95(Suppl. 4):162-3. ASAS-CSAS Annual Meeting & Trade Show, Baltimore, MD, USA, 2017. doi: https://doi.org/10.2527/asasann.2017.328