Srihari Radhakrishnan

Dr. Srihari Radhakrishnan

Position
  • Former Graduate Student
I completed my Ph.D. in 2015 in the Bioinformatics and Computational Biology graduate program at Iowa State University. For my dissertation I worked in the transcriptomic and epigenetic basis of gonadal development in turtles and the consequences of sex-linkage in molecular evolution. My work was funded in part by Sigma Xi and by the National Science Foundation (MCB 1244355 and IOS 0743284) to Dr. Valenzuela.

I am now a Bioinformatics Scientist at Arc Bio, LLC.
Social Media and Websites

Education

  • Ph.D., Bioinformatics and Computational Biology, Iowa State University, 2015

More Information

7. Radhakrishnan S, Literman R, Neuwald JL, and Valenzuela N. 2018. Thermal response of epigenetic genes informs turtle sex determination with and without sex chromosomes. Sexual Development. 12:308–319.

6. Radhakrishnan S and Valenzuela N. 2017. Chromosomal context affects the molecular evolution of sex-linked genes and their autosomal counterparts in turtles and other vertebrates. Journal of Heredity. 108:720-730

5. Radhakrishnan S, Literman R, Mizoguchi B, and Valenzuela N. 2017. MeDIPseq and nCpG analyses illuminate sexually dimorphic methylation of gonadal development genes with high historic methylation in turtle hatchlings with temperature-dependent sex determination. Epigenetics & Chromatin. DOI 10.1186/s13072-017-0136-2

4. Literman R, S. Radhakrishnan, J. Tamplin, R. Burke, C. Dresser, and Valenzuela N. 2017. Development of sexing markers in Glyptemys insculpta and Apalone spinifera turtles uncovers an XX/XY sex-determining system in the critically-endangered bog turtle Glyptemys muhlenbergii.Conservation Genetic Resources. DOI 10.1007/s12686-017-0711-7

3. Radhakrishnan S, R Literman, J Neuwald, A Severin, and Valenzuela N. Transcriptomic responses to environmental temperature by turtles with temperature-dependent and genotypic sex determination assessed by RNAseq inform the genetic architecture of embryonic gonadal development. 2017. PLoS ONE 12(3): e0172044.

2. Badenhorst D, LD Hillier, R Literman, EE Montiel, S Radhakrishnan, P Minx, DE Janes, WC Warren, SV Edwards, and N Valenzuela. 2015. Physical mapping and refinement of the painted turtle genome (Chrysemys picta) inform amniote genome evolution and challenges turtle-bird chromosomal conservation. Genome Biology and Evolution D7(7):2038–2050.

1. Shaffer HB, P Minx, DE Warren, AM Shedlock, RC Thomson, N Valenzuela,.... S Radhakrishnan et 40 altri. 2013. The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage. Genome Biology. doi:10.1186/gb-2013-14-3-r28