Dr. Khaled Kamal’s research investigates the complex interplay of mechanotransduction and reactive oxygen species (ROS) regulation in skeletal muscle atrophy and damage. By studying the molecular and cellular pathways driving muscle adaptation under conditions such as mechanical unloading, aging sarcopenia, neuromuscular diseases like Duchenne Muscular Dystrophy (DMD), and spaceflight-induced disuse, this work aims to mitigate muscle degeneration. Dr. Kamal employs innovative in vitro, ex vivo, and in vivo models to identify key molecular players and develop therapeutic targets.
This research integrates mechanotransduction signaling, redox biology, and cutting-edge interventions to enhance muscle resilience, bridging foundational discoveries with translational applications for chronic diseases and the challenges of space exploration.