Publications

Fierro MA, Muheliji A, Sha J, Wohlschlegel JA, Beck JR. PEXEL is a proteolytic maturation site for both exported and non-exported Plasmodium proteins. mSphere. 2024 Feb 9 9:e0039323. PubMed PMID: 38334391.

Fierro MA, Hussain T, Campin LJ, Beck JR. Knock-sideways by inducible ER retrieval enables a unique approach for studying Plasmodium-secreted proteins. PNAS. 2023 Aug 15;120(33):e2308676120. PubMed PMID: 37552754.

Hussain T, Linera-Gonzalez J, Beck JM, Fierro MA, Mair GR, Smith RC, Beck JR. The PTEX pore component EXP2 is important for intrahepatic development during the Plasmodium liver stage. mBio. 2022 Nov 29;e0309622. PubMed PMID: 36445080.

Chheda P, Nieto N, Kaur S, Beck JM, Beck JR, Kerns R, Honzatko, RB, Nelson SW. Promising antimalarials targeting apicoplast DNA polymerase from Plasmodium falciparum. Eur J Med Chem. 2022 Dec 5;243:114751. PubMed PMID: 36191407.

Ambekar S, Beck JR^†, Mair GR^†. TurboID identification of evolutionarily divergent components of the nuclear pore complex in the malaria model Plasmodium berghei. mBio. 2022 Oct 26;13(5):e0181522. PubMed PMID: 36040030.

Kaur S, Nieto N, McDonald P, Beck JR, Honzatko, RB, Nelson SW. Discovery of small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase. J Enzyme Inhib Med Chem. 2022 Dec;37(1):1320-1326. PubMed PMID: 35514163.

Ahiya A, Bhatnagar S, Morrisey J, Beck JR, Vaidya A. Dramatic consequences of reducing erythrocyte membrane cholesterol on Plasmodium falciparum. Microbiol Spectr. 2022;10(1):e00158-22. PubMed PMID: 35196803.

Ho CM, Jih J, Lai M, Li X, Goldberg DE, Beck JR, Zhou ZH. Native structure of the RhopH complex, a key determinant of malaria parasite nutrient acquisition. PNAS. 2021;118(35):e2100514118. PubMed PMID: 34446549.

Garten M^† and Beck JR^†. Structured to conquer: transport across the Plasmodium parasitophorous vacuole. Curr Opin Microbiol. 2021 Aug 7;63:181-188. PubMed PMID: 34375857.

Beck JR^† and Ho CM^†. Transport mechanisms at the malaria parasite-host cell interface. PLoS Pathog. 2021 Apr 1;17(4): e1009394. PubMed PMID: 33793667.

Garten M, Beck JR, Roth R, Tenkova-Heuser T, Heuser J, Istvan E, Bleck CKE, Goldberg DE, Zimmerberg J. Contacting domains segregate a lipid transporter from a solute transporter in the malarial host-parasite interface. Nature Communications. 2020 Jul 30;11(1):3825. PubMed PMID: 32732874.

Nessel T, Beck JM, Rayatpisheh S, Jami-Alahmadi Y, Wohlschlegel JA, Goldberg DE, Beck JR. EXP1 is required for organization of EXP2 in the intraerythrocytic malaria parasite vacuole. Cellular Microbiology. 2020 Jan 28:e13168. PubMed PMID: 31990132.

Matz JM, Beck JR, Blackman MJ. The parasitophorous vacuole of the blood-stage malaria parasite. Nature Reviews Microbiology. 2020 Jan 24. PubMed PMID: 31980807.

Ho CM, Li X, Lai M, Terwilliger TC, Beck JR, Wohlschlegel J, Goldberg DE, Fitzpatrick AWP, Zhou ZH. Bottom-up structural proteomics: cryoEM of protein complexes enriched from the cellular milieu. Nature Methods. 2020 Jan;17(1):79-85. PubMed PMID: 31768063.

Istvan ES, Das S, Bhatnagar S, Beck JR, Owen E, Llinas M, Ganesan SM, Niles JC, Winzeler E, Vaidya AB, Goldberg DE. Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis. Elife. 2019 Mar 19;8. pii: e40529. PubMed PMID: 30888318.

Ho CM, Beck JR, Lai M, Cui Y, Goldberg DE, Egea PF, Zhou ZH. Malaria parasite translocon structure and mechanism of effector export. Nature. 2018 Sep;561(7721):70-75. PubMed PMID: 30150771.

Garten M, Nasamu AS, Niles JC, Zimmerberg J, Goldberg DE, Beck JR. EXP2 is a nutrient-permeable channel in the vacuolar membrane of Plasmodium and is essential for protein export via PTEX. Nature Microbiology. 2018 Oct;3(10):1090-1098. PubMed PMID: 30150733.

Glushakova S, Beck JR, Garten M, Busse BL, Nasamu AS, Tenkova-Heuser T, Heuser J, Goldberg DE, Zimmerberg J. Rounding precedes rupture and breakdown of vacuolar membranes minutes before malaria parasite egress from erythrocytes. Cellular Microbiology. 2018 Oct;20(10):e12868. PubMed PMID: 29900649

Nasamu AS, Glushakova S, Russo I, Vaupel B, Oksman A, Kim AS, Fremont DH, Tolia N, Beck JR, Meyers MJ, Niles JC, Zimmerberg J, Goldberg DE. Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion. Science. 2017 Oct 27;358(6362):518-522. PubMed PMID: 29074774.

Glushakova S, Busse BL, Garten M, Beck JR, Fairhurst RM, Goldberg DE, Zimmerberg J. Exploitation of a newly-identified entry pathway into the malaria parasite-infected erythrocyte to inhibit parasite egress. Science Reports. 2017 Sep 25;7(1):12250. PubMed PMID: 28947749.

Spillman NJ, Beck JR, Ganesan SM, Niles JC, Goldberg DE. The chaperonin TRiC forms an oligomeric complex in the malaria parasite cytosol. Cellular Microbiology. 2017 Jun;19(6). PubMed PMID: 28067475.

Gold DA, Kaplan AD, Lis A, Bett GC, Rosowski EE, Cirelli KM, Bougdour A, Sidik SM, Beck JR, Lourido S, Egea PF, Bradley PJ, Hakimi MA, Rasmusson RL, Saeij JP. The Toxoplasma Dense Granule Proteins GRA17 and GRA23 Mediate the Movement of Small Molecules between the Host and the Parasitophorous Vacuole. Cell Host & Microbe. 2015 May 13;17(5):642-52. PubMed PMID: 25974303.

Spillman NJ*, Beck JR*, Goldberg DE. Protein export into malaria parasite-infected erythrocytes: mechanisms and functional consequences. Annual Reviews of Biochemistry. 2015; 84:813-41. PubMed PMID: 25621510.

Beck JR*, Muralidharan V*, Oksman A, Goldberg DE. PTEX component HSP101 mediates export of diverse malaria effectors into host erythrocytes. Nature. 2014 Jul 31;511(7511):592-5. PubMed PMID: 25043010.

Tonkin ML, Beck JR, Bradley PJ, Boulanger MJ. The inner membrane complex sub-compartment proteins critical for replication of the apicomplexan parasite Toxoplasma gondii adopt a pleckstrin homology fold. Journal of Biological Chemistry. 2014 May 16;289(20):13962-73. PubMed PMID:24675080.

Beck JR, Chen AL, Kim EW, Bradley PJ. RON5 is critical for organization and function of the Toxoplasma moving junction complex. PLoS Pathogens. 2014 Mar 20;10(3):e1004025. PubMed PMID: 24651769.

Child MA, Hall CI, Beck JR, Ofori LO, Albrow VE, Garland M, Bowyer PW, Bradley PJ, Powers JC, Boothroyd JC, Weerapana E, Bogyo M. Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion. Nature Chemical Biology. 2013 Oct;9(10):651-6. PubMed PMID: 23934245.

de Leon JC, Scheumann N, Beatty W, Beck JR, Tran JQ, Yau C, Bradley PJ, Gull K, Wickstead B, Morrissette NS. A SAS-6-like protein suggests that the Toxoplasma conoid complex evolved from flagellar components. Eukaryotic Cell. 2013 Jul;12(7):1009-19. PubMed PMID:23687115.

Beck JR, Fung C, Straub KW, Coppens I, Vashisht AA, Wohlschlegel JA, Bradley PJ. A Toxoplasma palmitoyl acyl transferase and the palmitoylated armadillo repeat protein TgARO govern apical rhoptry tethering and reveal a critical role for the rhoptries in host cell invasion but not egress. PLoS Pathogens. 2013 Feb;9(2):e1003162. PubMed PMID: 23408890.

Anderson-White B, Beck JR, Chen CT, Meissner M, Bradley PJ, Gubbels MJ. Cytoskeleton assembly in Toxoplasma gondii cell division. International Review of Cell & Molecular Biology. 2012;298:1-31. PubMed PMID:22878103.

Tonkin ML, Brown S, Beck JR, Bradley PJ, Boulanger MJ. Purification, crystallization and preliminary X-ray diffraction analysis of inner membrane complex (IMC) subcompartment protein 1 (ISP1) from Toxoplasma gondii. Acta Crystallographica Section F. 2012 Jul 1;68(Pt 7):832-4. PubMed PMID: 22750877.

Fung C*, Beck JR*, Robertson SD, Gubbels MJ, Bradley PJ. Toxoplasma ISP4 is a central IMC sub-compartment protein whose localization depends on palmitoylation but not myristoylation. Molecular & Biochemical Parasitology. 2012 Aug;184(2):99-108. PubMed PMID: 22659420.

Beck JR, Rodriguez-Fernandez IA, de Leon JC, Huynh MH, Carruthers VB, Morrissette NS, Bradley PJ. A novel family of Toxoplasma IMC proteins displays a hierarchical organization and functions in coordinating parasite division. PLoS Pathogens. 2010 Sep 9;6(9):e1001094. PubMed PMID: 20844581.